Product References
The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner.
PLoS biology
Tóth K,Lénárt N,Berki P,Fekete R,Szabadits E,Pósfai B,Cserép C,Alatshan A,Benkő S,Kiss D,Hübner CA,Gulyás A,Kaila K,Környei Z,Dénes Á
11-0043-82 was used in Flow Cytometry to investigate the function of NKCC1 ion transporter in microglia and inflammation in brain.
Sat Jan 01 00:00:00 UTC 2022
Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice.
Nature communications
Chandana M,Anand A,Ghosh S,Das R,Beura S,Jena S,Suryawanshi AR,Padmanaban G,Nagaraj VA
Published figure using CD4 monoclonal antibody (Product # 11-0043-82) in Flow Cytometry
Tue Jul 12 00:00:00 UTC 2022
Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice.
Molecular medicine (Cambridge, Mass.)
Xu Q,Zhang X,Li T,Shao S
11-0043-82 was used in Flow cytometry/Cell sorting to illustrate that exenatide restores systemic Th17/Treg balance via regulating FoxO1 pathway with the progression of diabetes in db/db mice.
Sat Dec 03 00:00:00 UTC 2022
Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice.
Molecular medicine (Cambridge, Mass.)
Xu Q,Zhang X,Li T,Shao S
11-0043-82 was used in Flow cytometry/Cell sorting to illustrate that exenatide restores systemic Th17/Treg balance via regulating FoxO1 pathway with the progression of diabetes in db/db mice.
Sat Dec 03 00:00:00 UTC 2022
Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.
Cancer discovery
Lander VE,Belle JI,Kingston NL,Herndon JM,Hogg GD,Liu X,Kang LI,Knolhoff BL,Bogner SJ,Baer JM,Zuo C,Borcherding NC,Lander DP,Mpoy C,Scott J,Zahner M,Rogers BE,Schwarz JK,Kim H,DeNardo DG
11-0043-82 was used in Flow Cytometry to show that FAK inhibition allows RT to prime tumor immunity and unlock responsiveness to checkpoint immunotherapy.
Fri Dec 02 00:00:00 UTC 2022
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
11-0043-82 was used in Flow Cytometry to provide a window of opportunity for replication of oncolytic VSV and rationale for a paradigm change in oncolytic virotherapy, whereby immune responses could be intentionally induced against a VSV-encoded melanoma-associated antigen to improve safety without abrogating oncolysis.
Tue Jul 27 00:00:00 UTC 2021
Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Zhou J,Lu Y,Wu W,Feng Y
11-0043-82 was used in Flow Cytometry to show that the restoration of Treg populations by taurine normalizes the inflammatory response, reduces AR symptomology, and reduces histopathologic signs of AR.
Sat Jun 19 00:00:00 UTC 2021
The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24.
Immunity
Chong WP,Mattapallil MJ,Raychaudhuri K,Bing SJ,Wu S,Zhong Y,Wang W,Chen Z,Silver PB,Jittayasothorn Y,Chan CC,Chen J,Horai R,Caspi RR
11-0043 was used in Immunocytochemistry-immunoflourescence to report that Th17 cells are regulated by their own signature cytokine, IL-17A.
Tue Aug 18 00:00:00 UTC 2020
Delayed Akt suppression in the lipopolysaccharide-induced acute lung injury promotes resolution that is associated with enhanced effector regulatory T cells.
American journal of physiology. Lung cellular and molecular physiology
Artham S,Verma A,Alwhaibi A,Adil MS,Manicassamy S,Munn DH,Somanath PR
11-0043 was used in Flow cytometry/Cell sorting to identify a potential target for the treatment of late-stage ALI by promoting resolution through effector Treg-mediated suppression of inflammation.
Wed Apr 01 00:00:00 UTC 2020
Atherogenesis in the Carotid Artery with and without Interrupted Blood Flow of Two Hyperlipidemic Mouse Strains.
Journal of vascular research
Zhao J,Huangfu C,Chang Z,Grainger AT,Liu Z,Shi W
11-0043 was used in Flow cytometry/Cell sorting to examine artherogenesis in the left carotid artery with and without interrupted blood flow using mouse models.
Mon Jan 27 00:00:00 UTC 2020
Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma.
Experimental and therapeutic medicine
Wei Y,Zhang Z,Wang F,Zhou S
Published figure using CD4 monoclonal antibody (Product # 11-0043-82) in Flow Cytometry
Mon Jan 01 00:00:00 UTC 2018
Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system.
Oncoimmunology
Maxwell R,Luksik AS,Garzon-Muvdi T,Hung AL,Kim ES,Wu A,Xia Y,Belcaid Z,Gorelick N,Choi J,Theodros D,Jackson CM,Mathios D,Ye X,Tran PT,Redmond KJ,Brem H,Pardoll DM,Kleinberg LR,Lim M
11-0043 was used in Flow cytometry/Cell sorting to determine how corticosteroids influence anti-programmed cell death protein 1 responses and whether their effects are dependent on tumour location within the periphery versus central nervous system.
Wed Nov 03 00:00:00 UTC 2021
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM.
Oncoimmunology
Hung AL,Maxwell R,Theodros D,Belcaid Z,Mathios D,Luksik AS,Kim E,Wu A,Xia Y,Garzon-Muvdi T,Jackson C,Ye X,Tyler B,Selby M,Korman A,Barnhart B,Park SM,Youn JI,Chowdhury T,Park CK,Brem H,Pardoll DM,Lim M
11-0043 was used in Flow cytometry/Cell sorting to determine the effect of anti-PD-1 and anti-TIGIT combination therapy on survival in a murine glioblastoma model, and to elucidate the underlying immune mechanisms.
Wed Nov 03 00:00:00 UTC 2021
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.
Circulation research
Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ
11-0043 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.
Fri May 12 00:00:00 UTC 2017
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.
The Journal of allergy and clinical immunology
Stentzel S,Teufelberger A,Nordengrün M,Kolata J,Schmidt F,van Crombruggen K,Michalik S,Kumpfmüller J,Tischer S,Schweder T,Hecker M,Engelmann S,Völker U,Krysko O,Bachert C,Bröker BM
11-0043 was used in Flow cytometry/Cell sorting to identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.
Wed Feb 01 00:00:00 UTC 2017
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Journal of immunology (Baltimore, Md. : 1950)
Marshall NB,Vong AM,Devarajan P,Brauner MD,Kuang Y,Nayar R,Schutten EA,Castonguay CH,Berg LJ,Nutt SL,Swain SL
11004382 was used in flow cytometry to determine that NKG2C/E identifies the CD4 T cell effector subset ThCTL that develop in the lung during influenza A virus infection in mice
Wed Feb 01 00:00:00 UTC 2017
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
11-0043 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 UTC 2017
Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice.
BMC immunology
Ni G,Liao Z,Chen S,Wang T,Yuan J,Pan X,Mounsey K,Cavezza S,Liu X,Wei MQ
11-0043 was used in Flow cytometry/Cell sorting to determine the effect of blocking IL-10 during immunisation on intestinal inflammation responses.
Tue Aug 15 00:00:00 UTC 2017
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
11-0043 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 UTC 2016
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
Nature communications
Gautheron J,Vucur M,Schneider AT,Severi I,Roderburg C,Roy S,Bartneck M,Schrammen P,Diaz MB,Ehling J,Gremse F,Heymann F,Koppe C,Lammers T,Kiessling F,Van Best N,Pabst O,Courtois G,Linkermann A,Krautwald S,Neumann UP,Tacke F,Trautwein C,Green DR,Longerich T,Frey N,Luedde M,Bluher M,Herzig S,Heikenwalder M,Luedde T
Published figure using CD4 monoclonal antibody (Product # 11-0043-82) in Immunohistochemistry
Tue Jun 21 00:00:00 UTC 2016
Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.
Nature communications
Szalay G,Martinecz B,Lénárt N,Környei Z,Orsolits B,Judák L,Császár E,Fekete R,West BL,Katona G,Rózsa B,Dénes Á
11-0043 was used in Flow cytometry/Cell sorting to investigate the influence of microglia on neuronal activity and survival in the injured brain in vivo.
Tue May 03 00:00:00 UTC 2016
Tregs Modulate Lymphocyte Proliferation, Activation, and Resident-Memory T-Cell Accumulation within the Brain during MCMV Infection.
PloS one
Prasad S,Hu S,Sheng WS,Singh A,Lokensgard JR
11-0043 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T-cells within the mouse brain during murine cytomegalovirus infection.
Mon Jun 27 00:00:00 UTC 2016
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Nature
Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J
11-0043 was used in Immunofluorescence to show that a subset of alveolar macrophages (AMs) attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with the epithelium.
Thu Feb 27 00:00:00 UTC 2014
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
11-0043 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 UTC 2013
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
11-0043 was used in Flow cytometry/Cell sorting to reveal TDP2-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2-induced DSBs.
Thu Jun 13 00:00:00 UTC 2013
Protective CD8 memory T cell responses to mouse melanoma are generated in the absence of CD4 T cell help.
PloS one
Côté AL,Byrne KT,Steinberg SM,Zhang P,Turk MJ
11-0043 was used in Flow cytometry/Cell sorting to support further use of CD4 T cell depletion therapy for inducing long-lived immunity to cancer.
Mon Mar 26 00:00:00 UTC 2012
MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance to murine cytomegalovirus.
Journal of immunology (Baltimore, Md. : 1950)
Xie X,Stadnisky MD,Brown MG
11-0043 was used in Flow cytometry/Cell sorting to investigate resistance to murine cytomegalovirus, showing that the MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance.
Mon Jun 01 00:00:00 UTC 2009
IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host.
Journal of immunology (Baltimore, Md. : 1950)
Liu XS,Leerberg J,MacDonald K,Leggatt GR,Frazer IH
11-0043 was used in Flow cytometry/Cell sorting to study the mechanism by which CD8 T cell response is inhibited by CD4(+) T cells in antigen-experienced hosts, showing that IL-10 secretion by CD4(+) cells is enhanced by IFM-gamma signalling, which then inhibits CD8 generation, suggesting that inhibition of IL-10 and IFN-gamma could increase antitumor effect when used in conjunction with antigen immunotherapy.
Wed Jul 01 00:00:00 UTC 2009
IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host.
Journal of immunology (Baltimore, Md. : 1950)
Liu XS,Leerberg J,MacDonald K,Leggatt GR,Frazer IH
11-0043 was used in Flow cytometry/Cell sorting to study the mechanism by which CD8 T cell response is inhibited by CD4(+) T cells in antigen-experienced hosts, showing that IL-10 secretion by CD4(+) cells is enhanced by IFM-gamma signalling, which then inhibits CD8 generation, suggesting that inhibition of IL-10 and IFN-gamma could increase antitumor effect when used in conjunction with antigen immunotherapy.
Wed Jul 01 00:00:00 UTC 2009
Protein kinase C theta plays a fundamental role in different types of chronic colitis.
Gastroenterology
Nagahama K,Ogawa A,Shirane K,Shimomura Y,Sugimoto K,Mizoguchi A
11-0043 was used in Magnetic cell separation to demonstrate that protein kinase C is a common and fundamental signaling molecule in colitis development.
Fri Feb 01 00:00:00 UTC 2008
