Invitrogen

CD119 (IFN gamma Receptor 1) Monoclonal Antibody (2E2), Biotin, eBioscience™

CD119 (IFN gamma Receptor 1) Antibody in Flow Cytometry (Flow)

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CD119 (IFN gamma Receptor 1) Antibody (13-1191-82) in Flow

Staining of BALB/c splenocytes with 0.5 µg of Armenian Hamster IgG Isotype Control Biotin (Product # 13-4888-81) (blue histogram) or 0.5 µg of Anti-Mouse CD119 (IFN gamma Receptor 1) Biotin (purple histogram) followed by Streptavidin PE (Product # 12-4317-87). Total viable cells were used for analysis.

CD119 (IFN gamma Receptor 1) Antibody in Immunocytochemistry (ICC/IF)

CD119 (IFN gamma Receptor 1) Antibody in Immunohistochemistry (IHC)

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产品信息

13-1191-82

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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免疫细胞化学 (ICC/IF)

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流式细胞分析 (Flow)

1 µg/test

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产品规格

种属反应

Mouse

已发表种属

Human, Mouse

宿主/亚型

Armenian hamster / IgG

分类

Monoclonal

类型

Antibody

克隆号

2E2

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2572773

产品详细信息

Description: The monoclonal antibody 2E2 recognizes mouse CD119 also known as IFN gamma receptor1. CD119 heterodimerizes with IFN gamma receptor 2 (AF-1) forming the Class II cytokine receptor. The ligand IFN gamma binds IFN gamma receptor 1 subunit but signal transduction transpires via the IFN gamma receptor 2 subunit. The receptor is involved in host defense and expression is broad including B cells, NK cells, macrophages and dendritic cells as well as other non-hematopoietic cell types.

Applications Reported: This 2E2 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This 2E2 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity.

Cancer discovery

Chen HA,Ho YJ,Mezzadra R,Adrover JM,Smolkin R,Zhu C,Woess K,Bernstein N,Schmitt G,Fong L,Luan W,Wuest A,Tian S,Li X,Broderick C,Hendrickson RC,Egeblad M,Chen Z,Alonso-Curbelo D,Lowe SW

Published figure using CD119 (IFN gamma Receptor 1) monoclonal antibody (Product # 13-1191-82) in Flow Cytometry

Mon Feb 06 00:00:00 UTC 2023

STUB1 is an intracellular checkpoint for interferon gamma sensing.

Scientific reports

Ng S,Lim S,Sim ACN,Mangadu R,Lau A,Zhang C,Martinez SB,Chandramohan A,Lim UM,Ho SSW,Chang SC,Gopal P,Hong LZ,Schwaid A,Fernandis AZ,Loboda A,Li C,Phan U,Henry B,Partridge AW

Published figure using CD119 (IFN gamma Receptor 1) monoclonal antibody (Product # 13-1191-82) in Flow Cytometry

Thu Aug 18 00:00:00 UTC 2022

The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome.

Journal of neuroinflammation

Smith BC,Sinyuk M,Jenkins JE,Psenicka MW,Williams JL

13-1191 was used in Immunohistochemistry to reveal a protective role for IFNγ in chronic neuroinflammation and identify a novel function of the iP in astrocytes during CNS autoimmunity.

Fri Jun 12 00:00:00 UTC 2020

The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome.

Journal of neuroinflammation

Smith BC,Sinyuk M,Jenkins JE,Psenicka MW,Williams JL

13-1191 was used in Immunohistochemistry to reveal a protective role for IFNγ in chronic neuroinflammation and identify a novel function of the iP in astrocytes during CNS autoimmunity.

Fri Jun 12 00:00:00 UTC 2020

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research

Moreira D,Adamus T,Zhao X,Su YL,Zhang Z,White SV,Swiderski P,Lu X,DePinho RA,Pal SK,Kortylewski M

13-1191 was used in Flow cytometry/Cell sorting to show a novel strategy combining STAT3 inhibition with Toll-like Receptor 9 (TLR9) stimulation to unleash immune response against prostate cancers regardless of the genetic background.

Sat Dec 01 00:00:00 UTC 2018

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.

PLoS pathogens

Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP

13-1191-82 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.

Fri Sep 01 00:00:00 UTC 2017

Mycolactone displays anti-inflammatory effects on the nervous system.

PLoS neglected tropical diseases

Isaac C,Mauborgne A,Grimaldi A,Ade K,Pohl M,Limatola C,Boucher Y,Demangel C,Guenin-Macé L

Published figure using CD119 (IFN gamma Receptor 1) monoclonal antibody (Product # 13-1191-82) in Flow Cytometry

Wed Nov 01 00:00:00 UTC 2017

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity.

Nature communications

Peske JD,Thompson ED,Gemta L,Baylis RA,Fu YX,Engelhard VH

13119182 was used in flow cytometry to find that lymph node-like vasculature in melanoma and lung carcinoma murine models is both a consequence of and key contributor to anti-tumor immunity

Wed May 13 00:00:00 UTC 2015

A role for the ITAM signaling module in specifying cytokine-receptor functions.

Nature immunology

Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

Published figure using CD119 (IFN gamma Receptor 1) monoclonal antibody (Product # 13-1191-82) in Immunofluorescence

Tue Apr 01 00:00:00 UTC 2014

A role for the ITAM signaling module in specifying cytokine-receptor functions.

Nature immunology

Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

Published figure using CD119 (IFN gamma Receptor 1) monoclonal antibody (Product # 13-1191-82) in Immunofluorescence

Tue Apr 01 00:00:00 UTC 2014

生物信息学

蛋白别名: CD119; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; INF-g receptor; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor 1

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基因别名: CD119; Ifgr; IFN-gammaR; Ifngr; Ifngr1; Nktar

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UniProt ID: (Mouse) P15261

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Entrez Gene ID: (Mouse) 15979

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功能

cytokine receptor activity cytokine binding transmembrane signal receptor

参与通路

cytokine-mediated signaling pathway