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14-3-3 sigma Antibody (PA5-87755) in IHC (P)
Immunohistochemistry analysis of 14-3-3 sigma in paraffin-embedded mouse skin. Samples were incubated with 14-3-3 sigma Polyclonal antibody (Product # PA5-87755) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-87755
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human 14-3-3 sigma (NP_0061331)
偶联物
形式
Liquid
浓度
1.50 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804389
产品详细信息
Immunogen sequence: MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL
Positive Samples: HT-29, MCF7; Cellular Location: Cytoplasm, Nucleus
靶标信息
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 14-3-3 protein sigma; 14-3-3 sigma; 14-3-3 sigma protein; 14-3-3sigma; Epithelial cell marker protein 1; HGNC:10773; Stratifin; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide
基因别名: Er; HME1; Mkrn3; Mme1; SFN; YWHAS
UniProt ID: (Human) P31947, (Mouse) O70456
Entrez Gene ID: (Human) 2810, (Mouse) 55948, (Rat) 313017
regulation of cyclin-dependent protein serine/threonine kinase activity
release of cytochrome c from mitochondria
keratinocyte development
negative regulation of protein kinase activity
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of epidermal cell division
negative regulation of keratinocyte proliferation
positive regulation of cell growth
keratinization
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of epidermal cell differentiation
positive regulation of protein export from nucleus
membrane organization
establishment of skin barrier
negative regulation of protein serine/threonine kinase activity
cell-cell adhesion
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
keratinocyte differentiation
skin development
regulation of cell cycle
biological_process
