Invitrogen

IL-6 Monoclonal Antibody (MQ2-13A5), Functional Grade, eBioscience™

IL-6 Antibody in Immunohistochemistry (IHC)

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IL-6 Antibody (16-7069-81) in IHC

Stem cells (Dayton, Ohio) 2017 - Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in Immunohistochemistry

IL-6 Antibody in T-Cell Activation (TCA)

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产品信息

16-7069-81

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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流式细胞分析 (Flow)

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酶联免疫吸附实验 (ELISA)

Assay-Dependent

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中和实验 (Neu)

Assay-Dependent

功能检测 (Functional)

Assay-Dependent

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T细胞活化 (TCA)

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其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rat / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

MQ2-13A5

偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

no preservative

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_469218

产品详细信息

Description: The MQ2-13A5 antibody reacts with human interleukin-6 (IL-6), a 21-28 kDa cytokine secreted by a variety of cell types.

Applications Reported: This MQ2-13A5 antibody has been reported for use in cytokine neutralization, ELISPOT, and ELISA capture.

Applications Tested: The MQ2-13A5 antibody has been tested for neutralizing IL-6 binding and biological activity.

Storage and handling: Use in a sterile environment.

Filtration: 0.2 µm post-manufacturing filtered.

Purity: Greater than 90%, as determined by SDS-PAGE.

Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.

Aggregation: Less than 10%, as determined by HPLC.

靶标信息

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways.

iScience

Ahmed A,Tripathi H,van Meijgaarden KE,Kumar NC,Adiga V,Rakshit S,Parthiban C,Eveline J S,D'Souza G,Dias M,Ottenhoff THM,Netea MG,Joosten SA,Vyakarnam A

Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in Flow Cytometry

Fri Oct 20 00:00:00 UTC 2023

CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase.

Hepatology (Baltimore, Md.)

Lin Y,Cai Q,Chen Y,Shi T,Liu W,Mao L,Deng B,Ying Z,Gao Y,Luo H,Yang X,Huang X,Shi Y,He R

16-7069-81 was used in Sample Preparation to investigate whether and how cancer-associated fibroblasts (CAFs) regulate myeloid-derived suppressor cells (MDSCs) function to enhance cancer stemness, the driving force of the cancer aggressiveness and chemotherapy refractoriness, in highly desmoplastic intrahepatic cholangiocarcinoma (ICC).RNA-sequencing analysis revealed enriched metabolic pathways but decreased inflammatory pathways in cancer MDSCs compared with blood MDSCs from patients with ICC.

Sat Jan 01 00:00:00 UTC 2022

Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer.

Cancer science

Zhang GQ,Jiao Q,Shen CT,Song HJ,Zhang HZ,Qiu ZL,Luo QY

Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in Flow Cytometry

Mon Mar 01 00:00:00 UTC 2021

PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages.

Scientific reports

Obst J,Hall-Roberts HL,Smith TB,Kreuzer M,Magno L,Di Daniel E,Davis JB,Mead E

Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in ELISA

Wed Oct 06 00:00:00 UTC 2021

Mesenchymal Stromal Cell-Derived Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Acquisition of Epithelial Stem-Like Cell Properties in Ameloblastoma Epithelial Cells.

Stem cells (Dayton, Ohio)

Jiang C,Zhang Q,Shanti RM,Shi S,Chang TH,Carrasco L,Alawi F,Le AD

16-7069 was used in Immunohistochemistry-immunofluorescence to isolate and characterise mesenchymal stromal cells (AM-MSC) and epithelial cells from follicular ameloblastoma, and demonstrate that in vitro AM-MSCs secrete higher levels of IL-6 as compared to epithelial cells.

Fri Sep 01 00:00:00 UTC 2017

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer.

Cell death & disease

Ramakrishnan S,Hu Q,Krishnan N,Wang D,Smit E,Granger V,Rak M,Attwood K,Johnson C,Morrison C,Pili R,Chatta G,Guru K,Gueron G,McNally L,Wang J,Woloszynska-Read A

16-7069 was used in Functional assays to show that non-cytotoxic nanomolar decitabine concentrations modify the bladder cancer transcriptome to activate NOTCH1 at the mRNA and protein level, increase double-stranded RNA sensors and CK5-dependent differentiation.

Thu Dec 14 00:00:00 UTC 2017

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer.

Cell death & disease

Ramakrishnan S,Hu Q,Krishnan N,Wang D,Smit E,Granger V,Rak M,Attwood K,Johnson C,Morrison C,Pili R,Chatta G,Guru K,Gueron G,McNally L,Wang J,Woloszynska-Read A

Thu Dec 14 00:00:00 UTC 2017

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.

Proceedings of the National Academy of Sciences of the United States of America

Zhou Q,Yu X,Demirkaya E,Deuitch N,Stone D,Tsai WL,Kuehn HS,Wang H,Yang D,Park YH,Ombrello AK,Blake M,Romeo T,Remmers EF,Chae JJ,Mullikin JC,Güzel F,Milner JD,Boehm M,Rosenzweig SD,Gadina M,Welch SB,Özen S,Topaloglu R,Abinun M,Kastner DL,Aksentijevich I

Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in Flow Cytometry

Tue Sep 06 00:00:00 UTC 2016

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease.

Proceedings of the National Academy of Sciences of the United States of America

Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in Flow Cytometry

Tue Sep 06 00:00:00 UTC 2016

TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.

PloS one

Reichwald K,Jørgensen TZ,Tougaard P,Skov S

Published figure using IL-6 monoclonal antibody (Product # 16-7069-81) in Flow Cytometry

Mon Sep 08 00:00:00 UTC 2014

生物信息学

蛋白别名: B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; H-IL-6; Hybridoma growth factor; IFN-beta-2; IL-6; ILN; Interferon beta-2; Interleukin; interleukin BSF-2; Interleukin-6; Interleukin6; M-IL-6; R-IL-6

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基因别名: BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6; IL6

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UniProt ID: (Human) P05231

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Entrez Gene ID: (Human) 3569

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功能

cytokine activity interleukin-6 receptor binding protein binding growth factor activity

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