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5-Carboxylcytosine Antibody (PA5-117752) in ICC/IF
Immunocytochemical analysis of 5-Carboxylcytosine in 293T cells using a 5-Carboxylcytosine polyclonal antibody (Product # PA5-117752) at a dilution of 1:500. The C293T cells were transfected with either the mouse FLAG-tagged wild-type Tet1 (Tet1 CD) or the catalytically inactive FLAG-tagged C-terminal domain of Tet1 (Tet1 mCD). They were stained with the 5-Carboxylcytosine antibody diluted at 1:500 and with... View More
产品信息
PA5-117752
产品规格
种属反应
Chemical
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
5-Carboxylcytosine nucleotide
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 30% glycerol
内含物
0.05% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2902366
靶标信息
5-carboxylcytosine is the final oxidized derivative of 5-methylcytosine, a type of DNA methylation. 5-methylcytosine is oxidized to 5-hydroxymethylcytosine which is then oxidized to 5-formylcytosine and later to 5-carboxylcytosine. These oxidations are catalyzed by the Ten-Eleven Translocation (TET) enzyme family. 5-carboxylcytosine has been shown to cause reduced fidelity of RNA Polymerase II. Decreased levels of 5-hydroxymethylcytosine has been found in some cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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