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CD66c Antibody (53-0667-42) in Flow
Normal human peripheral blood cells were stained with CD66 Monoclonal Antibody, APC (Product # 17-0668-42) and Mouse IgG1 kappa Isotype Control, Alexa Fluor 488 (Product # 53-4714-80) (left) or CD66c Monoclonal Antibody, Alexa Fluor 488 (right). Cells in the granulocyte gate were used for analysis.
产品信息
53-0667-42
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
KOR-SA3544
偶联物
激发/发射光谱
499/520 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2811855
产品详细信息
Description: This KOR-SA3544 monoclonal antibody reacts with human CD66c (also known as CEACAM6), which is one of the splice variants of CD66. CD66c is expressed on endothelial and epithelial cells, as well as on neutrophils and monocytes. Myeloma and cancer cells, such as B-cell acute lymphoblastic lymphomas, also express CD66c. Moreover, expression of this receptor can be induced on T cells, B cells, and CD16-negative NK cells. Like the other CD66 splice variants, CD66c is involved in cell adhesion and growth, neutrophil activation, and signaling. Moreover, expression of CD66c in leukemic cells has been correlated with BCR/ABL1 rearrangement. Finally, studies have shown that the CD66 variants interact with each other homo- and heterotypically.
Applications Reported: This KOR-SA3544 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This KOR-SA3544 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser
靶标信息
CEA Cell Adhesion Molecule 6 (CEACAM6) belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. CEACAM6 affects the sensitivity of tumor cells to adenovirus infection. The acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BGP; BGP-1; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66a; CD66c; CD66d; CD66e; CEA; CEACAM-1; CEACAM-3; CEACAM-5; CEACAM-6; CGM1; Cluster of Differentiation 66c; Non-specific crossreacting antigen; Normal cross-reacting antigen; pan CEACAM
基因别名: CD66c; CEACAM6; CEAL; NCA
UniProt ID: (Human) P40199
Entrez Gene ID: (Human) 4680
