Osenses

5HT2B R Polyclonal Antibody

2 篇参考文献

产品信息

OSS00420W-100UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:2,000

-

免疫组化 (IHC)

1:300-1:2,000

-

其他PubMed (Misc)

-

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产品规格

种属反应

Mouse

已发表种属

Not Applicable

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from aa region 390-440 of mouse 5HT2B receptor conjugated to blue carrier protein was used as the antigen

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide shares 92% identity with human sequence and 82% with rat.

Specificity of this antibody: 5HT2B receptor.

靶标信息

HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Cloning and functional characterization of the human 5-HT2B serotonin receptor.

FEBS letters

Schmuck K,Ullmer C,Engels P,Lübbert H

Mon Mar 28 00:00:00 UTC 1994

The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors.

FEBS letters

Choi DS,Birraux G,Launay JM,Maroteaux L

Mon Oct 03 00:00:00 UTC 1994

生物信息学

蛋白别名: 5-HT-2B; 5-HT-2F; 5-HT2b receptor; 5-hydroxytryptamine receptor 2B; 5HT2B Receptor; NP75 protein; Serotonin receptor 2B

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基因别名: 5-HT2B; AJ012488; AV377389; Htr2b

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UniProt ID: (Mouse) Q8JZK5

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Entrez Gene ID: (Mouse) 15559

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G-protein alpha-subunit binding signal transducer activity G-protein coupled receptor activity G-protein coupled serotonin receptor activity GTPase activator activity drug binding serotonin binding G-protein coupled receptor

参与通路

neural crest cell migration positive regulation of cytokine production positive regulation of endothelial cell proliferation G-protein coupled receptor internalization heart morphogenesis cardiac muscle hypertrophy cGMP biosynthetic process cellular calcium ion homeostasis smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway heart development behavior positive regulation of cell proliferation negative regulation of autophagy positive regulation of phosphatidylinositol biosynthetic process neural crest cell differentiation phosphatidylinositol 3-kinase signaling intestine smooth muscle contraction phosphorylation calcium-mediated signaling ion transmembrane transport vasoconstriction response to drug negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of GTPase activity embryonic morphogenesis positive regulation of cytokine secretion regulation of behavior positive regulation of nitric-oxide synthase activity release of sequestered calcium ion into cytosol positive regulation of cell division negative regulation of cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade protein kinase C signaling cellular response to amine stimulus cellular response to temperature stimulus cellular response to serotonin