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5HT2B Receptor (HTR2B) (extracellular) Antibody (ASR-035-200UL) in IHC
Expression of 5-Hydroxytryptamine receptor 2B in mouse cerebellum - Immunohistochemical staining of mouse cerebellum using Anti-5HT2B Receptor (HTR2B) (extracellular) Antibody (#ASR-035) (1:400). A. 5-HT2B staining (red), appears in neurons of the Purkinje layer (vertical arrows) and in the molecular layer (horizontal arrow). B. Nuclear staining using DAPI as the counterstaining (blue). C. Merged image of p... View More
产品信息
ASR-035-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KMSEQ STISEHILQK, corresponding to amino acid residues 6-20 of rat 5-Hydroxytryptamine receptor 2B, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-HT 2B receptor; 5-HT-2B; 5-HT-2F; 5-HT2B; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; 5HT2B Receptor; NP75 protein; Serotonin receptor 2B; Stomach fundus serotonin receptor
基因别名: 5-HT(2B); 5-HT-2B; 5-HT2B; AJ012488; AV377389; HTR2B; Srl
UniProt ID: (Human) P41595, (Mouse) Q8JZK5, (Rat) P30994
Entrez Gene ID: (Human) 3357, (Mouse) 15559, (Rat) 29581
neural crest cell migration
positive regulation of cytokine production
positive regulation of endothelial cell proliferation
G-protein coupled receptor internalization
heart morphogenesis
cardiac muscle hypertrophy
cGMP biosynthetic process
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
activation of phospholipase C activity
protein kinase C-activating G-protein coupled receptor signaling pathway
serotonin receptor signaling pathway
behavior
positive regulation of cell proliferation
negative regulation of autophagy
positive regulation of phosphatidylinositol biosynthetic process
neural crest cell differentiation
phosphatidylinositol 3-kinase signaling
intestine smooth muscle contraction
phosphorylation
calcium-mediated signaling
hepatic stellate cell activation
vasoconstriction
response to drug
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
positive regulation of GTPase activity
inositol phosphate metabolic process
embryonic morphogenesis
positive regulation of cytokine secretion
regulation of behavior
positive regulation of nitric-oxide synthase activity
release of sequestered calcium ion into cytosol
positive regulation of cell division
negative regulation of cell death
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
cellular response to amine stimulus
cellular response to temperature stimulus
cellular response to serotonin
smooth muscle contraction
signal transduction
phospholipase C-activating serotonin receptor signaling pathway
heart development
ion transmembrane transport
