Invitrogen

ABCA3 Polyclonal Antibody

ABCA3 Antibody in Immunocytochemistry (ICC/IF)

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ABCA3 Antibody (PA5-52478) in ICC/IF

Immunofluorescent staining of ABCA3 in human cell line HUVEC TERT2 using an ABCA3 Polyclonal Antibody (Product # PA5-52478) shows localization to nucleoplasm and cytosol.

ABCA3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ABCA3 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

ABCA3 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of ABCA3 demonstrates antibody specificity. Immunohistochemical analysis of ABCA3 using anti-ABCA3 Polyclonal Antibody (Product # PA5-52478), shows significant staining of ABCA3 in human lung and shows minimal or weak staining in human liver tissues. The relative expression levels of ABCA3 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-52478

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human ABCA3. Recombinant protein control fragment (Product #RP-102458).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2637524

产品详细信息

Immunogen sequence: MLRLTLGEYG RTVVPFSVPG TSQLGQQLSE HLKDALQAEG QEPREVLGDL EEFLIFRASV EGGGFNERCL VAASFRDVGE RTVVNALFNN QAYHSPATAL AVVDNLLFKL LCGPHASIVV SNFPQPRSAL QAAKDQFNEG

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.

靶标信息

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Development of human-derived, three-dimensional respiratory epithelial tissue constructs with perfusable microvasculature on a high-throughput microfluidics screening platform.

Biofabrication

Jung O,Tung YT,Sim E,Chen YC,Lee E,Ferrer M,Song MJ

PA5-52478 was used in Immunohistochemistry-immunofluorescence to develop two novel vascularized, LRT multi-chip models for the alveoli and the small airway.

Mon Feb 14 00:00:00 UTC 2022

Co-culture of type I and type II pneumocytes as a model of alveolar epithelium.

PloS one

Brookes O,Boland S,Lai Kuen R,Miremont D,Movassat J,Baeza-Squiban A

PA5-52478 was used in Immunocytochemistry to support the coculture of these two cell lines to produce a model which better represents the breadth of functions seen in native alveolar epithelium.

Fri Nov 12 00:00:00 UTC 2021

Co-culture of type I and type II pneumocytes as a model of alveolar epithelium.

PloS one

Brookes O,Boland S,Lai Kuen R,Miremont D,Movassat J,Baeza-Squiban A

PA5-52478 was used in Immunocytochemistry to support the coculture of these two cell lines to produce a model which better represents the breadth of functions seen in native alveolar epithelium.

Fri Nov 12 00:00:00 UTC 2021

生物信息学

蛋白别名: ABC transporter 3; ABC-C transporter; ATP-binding cassette 3; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette, sub-family A (ABC1), member 3; Phospholipid-transporting ATPase ABCA3; Xenobiotic-transporting ATPase ABCA3

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基因别名: ABC-C; ABC3; ABCA3; EST111653; LBM180; SMDP3

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UniProt ID: (Human) Q99758

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Entrez Gene ID: (Human) 21

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功能

transporter activity lipid transporter activity ATP binding ATPase activity, coupled to transmembrane movement of substances ATP-binding cassette (ABC) transporter primary active transporter transporter

参与通路

transport lipid transport response to drug cellular protein metabolic process response to glucocorticoid transmembrane transport