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ABCC9 Antibody (PA5-103640) in ICC/IF
Immunofluorescent analysis of ABCC9 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and ABCC9 polyclonal antibody (Product # PA5-103640) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-103640
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ABCC9(Accession O60706), corresponding to amino acid residues L1269-V1319.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852974
产品详细信息
Antibody detects endogenous levels of total ABCC9.
靶标信息
Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; FLJ36852; Sulfonylurea receptor 2
基因别名: ABC37; ABCC9; ATFB12; CANTU; CMD1O; SUR2
UniProt ID: (Human) O60706, (Rat) Q63563
Entrez Gene ID: (Human) 10060, (Rat) 25560
transporter activity
potassium channel activity
ATP binding
sulfonylurea receptor activity
potassium channel regulator activity
anion transmembrane-transporting ATPase activity
ion channel binding
drug binding
syntaxin binding
ATPase activity, coupled to transmembrane movement of substances
identical protein binding
ATP-binding cassette (ABC) transporter
potassium ion transport
signal transduction
potassium ion import
defense response to virus
transmembrane transport
anion transmembrane transport
regulation of cardiac conduction
substrate-dependent cell migration, cell contraction
metabolic process
response to drug
potassium ion transmembrane transport
