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产品信息
PA5-54024
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2637543
产品详细信息
Immunogen sequence: HMVQYFTAIG YPCPRYSNPA DFYVDLTSID RRSREQELAT REKAQSLAAL FLEKVRDLDD FLWKAETKDL DEDTCVESSV TPLDTNCLPS PTKMPGAVQQ FTTLIRRQIS NDFRDLP
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 74%.
靶标信息
ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.
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生物信息学
蛋白别名: ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP-binding cassette, subfamily G, member 8; MGC142217; sterolin 2; Sterolin-2; Sterolin2
基因别名: ABCG8; GBD4; STSL
UniProt ID: (Human) Q9H221
Entrez Gene ID: (Human) 64241
response to nutrient
excretion
negative regulation of intestinal phytosterol absorption
phospholipid transport
sterol transport
intestinal cholesterol absorption
cholesterol efflux
response to drug
cholesterol homeostasis
negative regulation of intestinal cholesterol absorption
transmembrane transport
