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ABHD4 Antibody (PA5-75867) in IHC (P)
Immunohistochemistry analysis of ABHD4 in paraffin-embedded human rectum carcinoma tissue (membrane and cytoplasmic staining) and negative control (right, with PBS only). Samples were incubated with ABHD4 polyclonal antibody (Product # PA5-75867) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-75867
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human ABHD4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2719595
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The α/β hydrolase superfamily is comprised of diverse members that are involved in important biochemical processes and related to various diseases. They have unrelated sequences, various substrates, and different kinds of catalytic activities, yet they share the same canonical α/β hydrolase fold, which consists of an eight-stranded parallel α/β structure. They are also characterized by a catalytic triad composed of a histidine, an acid and a nucleophile. Members of this superfamily are often drug targets for treating diseases, such as diabetes, Alzheimer's disease, obesity and blood clotting disorders. ABHD1 plays a role in metabolizing smoking xenobiotics. ABHD2 participates in the development of atherosclerosis. ABHD4 is involved in an alternative synthesis pathway of NAE. ABHD4 is a lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE) which participates in the biosynthesis of N-acyl ethanolamines. Mutations in ABHD5 contribute to Chanarin-Dorfman syndrome. ABDH6 may play a role in nervous system metabolism and signaling. ABHD14A is possibly involved in granule neuron development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (Lyso)-N-acylphosphatidylethanolamine lipase; Abhydrolase domain-containing protein 4; Alpha/beta hydrolase domain-containing protein 4; Alpha/beta-hydrolase 4; lyso-N-acylphosphatidylethanolamine lipase
Gene Aliases: 1110035H23Rik; ABH4; ABHD4; AI429574
UniProt ID: (Human) Q8TB40, (Mouse) Q8VD66
Entrez Gene ID: (Human) 63874, (Rat) 364380, (Mouse) 105501
hydrolase activity
carboxylic ester hydrolase activity
phospholipase activity
prenylcysteine methylesterase activity
lipase activity
1-oxa-2-oxocycloheptane lactonase activity
sulfolactone hydrolase activity
3,4-dihydrocoumarin hydrolase activity
butyrolactone hydrolase activity
endosulfan lactone lactonase activity
L-ascorbate 6-phosphate lactonase activity
Ser-tRNA(Thr) hydrolase activity
Ala-tRNA(Pro) hydrolase activity
Cys-tRNA(Pro) hydrolase activity
Ser(Gly)-tRNA(Ala) hydrolase activity
all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
retinyl-palmitate esterase activity
mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
methyl indole-3-acetate esterase activity
methyl salicylate esterase activity
methyl jasmonate esterase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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