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产品信息
OSA00079G-500UG
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from the extracellular domain of rat ACCN2 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
纯化类型
Ammonium sulfate precipitation
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse and shares 96% identity with human.
Specificity of this antibody: ASIC1.
靶标信息
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ACCN2 variant 3; acid sensing (proton gated) ion channel 1; acid sensing ion channel; acid sensing ion channel 1; acid-sensing (proton-gated) ion channel 1; Acid-sensing ion channel; Acid-sensing ion channel 1; acid-sensing ion channel 1a protein; Amiloride-sensitive cation channel 2, neuronal; ASIC1; BNaC2; Brain sodium channel 2; Cation channel, amiloride-sensitive, neuronal, 2; degenerin 2; hBNaC2; proton gated cation channel ASIC1
基因别名: ACCN2; AI843610; ASIC; ASIC1; ASIC1a; B530003N02Rik; BNAC2
UniProt ID: (Human) P78348, (Mouse) Q6NXK8, (Rat) P55926
Entrez Gene ID: (Human) 41, (Mouse) 11419, (Rat) 79123
transport
sodium ion transport
signal transduction
memory
associative learning
response to pH
response to acidic pH
ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
negative regulation of neurotransmitter secretion
sensory perception of sour taste
protein homotrimerization
calcium ion transmembrane transport
cellular response to pH
ion transport
cation transport
calcium ion transport
monovalent inorganic cation transport
sensory perception of pain
cation transmembrane transport
