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Product Details
PA5-68757
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the c terminal region of mouse ACD
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2688787
Product Specific Information
This target displays homology in the following species: Cow: 83%; Dog: 85%; Guinea Pig: 85%; Horse: 85%; Human: 85%; Mouse: 100%; Rat: 93%
Target Information
This gene encodes a uridine 5' -monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5' -monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5' -monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adrenocortical dysplasia protein; TPP 1; TPP I; TPPI
Gene Aliases: Acd
UniProt ID: (Mouse) Q5EE38
Entrez Gene ID: (Mouse) 497652
telomere maintenance
skeletal system development
urogenital system development
intracellular protein transport
telomere capping
embryonic limb morphogenesis
protection from non-homologous end joining at telomere
telomere assembly
negative regulation of telomere maintenance via telomerase
segmentation
positive regulation of telomerase activity
positive regulation of single-stranded telomeric DNA binding
protein localization to chromosome, telomeric region
Performance Guarantee
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