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ACE2 Antibody (OSA00281W-100UL) in IHC (P)
IHC-P on paraffin sections of mouse testis. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chr... View More
产品信息
OSA00281W-100UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from aa region 750-800 of mouse ACE2 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in rat.
Specificity of this antibody: ACE2.
靶标信息
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ACE 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin-converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; renal angiotensin-converting enzyme 2
基因别名: 2010305L05Rik; Ace2
UniProt ID: (Rat) Q5EGZ1, (Mouse) Q8R0I0
Entrez Gene ID: (Rat) 302668, (Mouse) 70008
angiotensin-mediated drinking behavior
regulation of systemic arterial blood pressure by renin-angiotensin
proteolysis
response to virus
receptor biosynthetic process
viral entry into host cell
receptor-mediated virion attachment to host cell
negative regulation of smooth muscle cell proliferation
maternal process involved in female pregnancy
negative regulation of ERK1 and ERK2 cascade
positive regulation of gap junction assembly
regulation of cardiac conduction
positive regulation of cardiac muscle contraction
