Invitrogen

ACMSD Polyclonal Antibody

ACMSD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ACMSD Antibody (PA5-82392) in IHC (P)

Immunohistochemical analysis of ACMSD in human kidney using ACMSD Polyclonal Antibody (Product # PA5-82392) shows moderate to strong cytoplasmic positivity in cells in tubules.

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ACMSD Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of ACMSD demonstrates antibody specificity. Immunohistochemical analysis of ACMSD using anti-ACMSD Polyclonal Antibody (Product #PA5-82392), shows significant staining of ACMSD in liver and shows minimal or weak staining in pancreas tissues. The relative expression levels of ACMSD within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-82392

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human ACMSD. Recombinant protein control fragment (Product #RP-90368).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2789551

产品详细信息

Immunogen sequence: GVFEKFPKLK VCFAHGGGAF PFTVGRISHG FSMRPDLCAQ DNPMNPKKYL GSFYTDALVH DPLSLKLLTD VIGKDKVILG TDYPFPLGEL EPGKLIESME EFDEETKNKL KAGNAL

靶标信息

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]

仅用于科研。不用于诊断过程。未经明确授权不得转售。