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ACOT2 Antibody (PA5-120270) in IHC (P)
Immunohistochemistry analysis of ACOT2 in paraffin-embedded human appendix. Samples were incubated with ACOT2 Polyclonal antibody (Product # PA5-120270) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-120270
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 222-483 of human ACOT2 (NP_006812.3).
偶联物
形式
Liquid
浓度
2.79 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913842
产品详细信息
Positive test controls include: 293T, LO2, U-87MG, Mouse kidney. The target is usually found in the following locations: Mitochondrion.
Immunogen sequence: IVDMFGTGGG LLEYRASLLA GKGFAVMALA YYNYEDLPKT METLHLEYFE EAMNYLLSHP EVKGPGVGLL GISKGGELCL SMASFLKGIT AAVVINGSVA NVGGTLHYKG ETLPPVGVNR NRIKVTKDGY ADIVDVLNSP LEGPDQKSFI PVERAESTFL FLVGQDDHNW KSEFYANEAC KRLQAHGRRK PQIICYPETG HYIEPPYFPL CRASLHALVG SPIIWGGEPR AHAMAQVDAW KQLQTFFHKH LGGHEGTIPS KV
靶标信息
Acyl-CoA thioesterases (ACOTs) are a group of enzymes that catalyze the hydrolysis of acyl-CoA to form coenzyme A (CoA) and a free fatty acid. Through their catalytic activity, ACOTs are able to regulate the level of fatty acids and acyl-CoAs within the cell. ACOT1 (acyl-CoA thioesterase 1, also known as CTE1) and ACOT2 (acyl-CoA thioesterase 2, also known as PTE2) are members of the ACOT family and exhibit different cellular localization, with ACOT1 existing as a monomer in the cytoplasm and ACOT2 localized primarily to mitochondria. Characteristic of most ACOT proteins, ACOT1 and ACOT2 catalyze the conversion of Palmitoyl-CoA and water to free CoA and palmitate, a reaction that is important for the regulation of intercellular fatty acid levels. ACOT2 is expressed as multiple alternatively spliced isoforms and, like ACOT1, is encoded by a gene which maps to human chromosome 14.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterase 2; Acyl-coenzyme A thioester hydrolase 2a; Acyl-coenzyme A thioesterase 2, mitochondrial; ARTISt/p43; CTE Ia; CTE-Ia; Long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; MTE-I; peroxisomal long-chain acyl-coA thioesterase 2; Very-long-chain acyl-CoA thioesterase; ZAP128
基因别名: AA571646; ACOT2; CTE-IA; CTE1A; MTE-I; MTE1; PTE2; PTE2A; ZAP128
UniProt ID: (Human) P49753, (Mouse) Q9QYR9
Entrez Gene ID: (Human) 10965, (Mouse) 171210, (Rat) 192272
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
acyl-CoA metabolic process
long-chain fatty-acyl-CoA biosynthetic process
response to hypoxia
very long-chain fatty acid catabolic process
response to hormone
response to nutrient levels
response to drug
response to epidermal growth factor
