Search Thermo Fisher Scientific
Immunogen sequence: STPKNGMSSK SRKRIMPDPV TEPPVTDPVY EALLYCNIPS VAERSMEGHA PHHFKLVSVH VFIRHGDRYP LYVIPKTKRP EIDCTLVANR KPYHPKLEAF ISHMSKGSGA SFESPLNSLP LYPNHP
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.
Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 2-phosphoxylose phosphatase 1; acid phosphatase-like 2; Acid phosphatase-like protein 2; epididymis luminal protein 124; PXYLP1 (HGNC:26303); Xylosyl phosphatase
基因别名: ACPL2; HEL124; PXYLP1; UNQ370/PRO706; XYLP
UniProt ID: (Human) Q8TE99
Entrez Gene ID: (Human) 92370