Invitrogen

ACSL3 Polyclonal Antibody

ACSL3 Antibody in Immunocytochemistry (ICC/IF)

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ACSL3 Antibody (PA5-42883) in ICC/IF

Immunofluorescence analysis of THP-1 derived macrophage cells using an anti-ACSL3 polyclonal antibody (Product # PA5-42883).

ACSL3 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-42883

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

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免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

1:200

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the N-terminal of human ACSL3 (aa 74-123).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2609901

产品详细信息

Peptide sequence: LDGLASVLYP GCDTLDKVFT YAKNKFKNKR LLGTREVLNE EDEVQPNGKI

Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 93%

靶标信息

An initial reaction in fatty acid metabolism in eukaryotic cells is activation of fatty acids catalyzed by acyl-CoA synthetase. FACL3 (fatty acid CoA ligase, long-chain 3) is identified as member of the acyl-CoA synthetase (ACS) family by PCR of rat brain cDNAs using primers based on the conserved region of the ACS protein. The 720-amino acid rat protein preferentially utilizes myristate, laurate, arachidonate, and eicosapentaenoate, and is expressed primarily in brain. The predicted 720-amino acid FACL3 human protein is 92% identical to that of rat.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis.

Cancer research communications

DiNatale A,Worrede A,Iqbal W,Marchioli M,Toth A,Sjöström M,Zhu X,Corey E,Feng FY,Zhou W,Fatatis A

PA5-42883 was used in Immunohistochemistry to show that secreted IL-1β supports metastatic progression in mice by altering the transcriptome of tumor-associated bone stroma.

Thu Dec 01 00:00:00 UTC 2022

IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis.

Cancer research communications

DiNatale A,Worrede A,Iqbal W,Marchioli M,Toth A,Sjöström M,Zhu X,Corey E,Feng FY,Zhou W,Fatatis A

PA5-42883 was used in Immunohistochemistry to show that secreted IL-1β supports metastatic progression in mice by altering the transcriptome of tumor-associated bone stroma.

Thu Dec 01 00:00:00 UTC 2022

Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer.

Molecular oncology

Fernández LP,Merino M,Colmenarejo G,Moreno-Rubio J,Sánchez-Martínez R,Quijada-Freire A,Gómez de Cedrón M,Reglero G,Casado E,Sereno M,Ramírez de Molina A

PA5-42883 was used in Western Blotting to understand the ability of ACSL3 as a prognostic biomarker for non-small cell lung cancer and its correlation with statin effectivity.

Tue Dec 01 00:00:00 UTC 2020

Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer.

Molecular oncology

Fernández LP,Merino M,Colmenarejo G,Moreno-Rubio J,Sánchez-Martínez R,Quijada-Freire A,Gómez de Cedrón M,Reglero G,Casado E,Sereno M,Ramírez de Molina A

PA5-42883 was used in Western Blotting to understand the ability of ACSL3 as a prognostic biomarker for non-small cell lung cancer and its correlation with statin effectivity.

Tue Dec 01 00:00:00 UTC 2020

TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.

Journal of lipid research

Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE

PA5-42883 was used in Western Blotting to investigate the effects of TNF-a on ACSLs and downstream lipids in cultured human coronary artery and umbilical vein endothelial cells.

Wed Jan 01 00:00:00 UTC 2020

Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.

Bioscience reports

Ndiaye H,Liu JY,Hall A,Minogue S,Morgan MY,Waugh MG

PA5-42883 was used in Western Blotting to conclude that analysis of ACSL3 and ACSL4 expression can distinguish different classes of hepatic tumours.

Thu Apr 30 00:00:00 UTC 2020

Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.

Bioscience reports

Ndiaye H,Liu JY,Hall A,Minogue S,Morgan MY,Waugh MG

PA5-42883 was used in Western Blotting to conclude that analysis of ACSL3 and ACSL4 expression can distinguish different classes of hepatic tumours.

Thu Apr 30 00:00:00 UTC 2020

Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.

Bioscience reports

Ndiaye H,Liu JY,Hall A,Minogue S,Morgan MY,Waugh MG

PA5-42883 was used in Western Blotting to conclude that analysis of ACSL3 and ACSL4 expression can distinguish different classes of hepatic tumours.

Thu Apr 30 00:00:00 UTC 2020

生物信息学

蛋白别名: Arachidonate--CoA ligase; Fatty acid CoA ligase Acsl3; fatty-acid-Coenzyme A ligase, long-chain 3; LACS 3; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 3; Long-chain-fatty-acid--CoA ligase 3; Medium-chain acyl-CoA ligase Acsl3

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基因别名: ACS3; ACSL3; FACL3; LACS3; PRO2194

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UniProt ID: (Human) O95573

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Entrez Gene ID: (Human) 2181

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功能

long-chain fatty acid-CoA ligase activity ATP binding protein kinase binding protein domain specific binding decanoate--CoA ligase activity ligase

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