Invitrogen

ACVR1 Polyclonal Antibody

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抗体检测数据 (1)

ACVR1 Antibody in Western Blot (WB)

ACVR1 Antibody in Western Blot (WB)

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ACVR1 Antibody (PA1-12641) in WB

Western blot analysis of ACVR1 using a polyclonal antibody (Product # PA1-12641).

ACVR1 Antibody in Western Blot (WB)

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ACVR1 Antibody in Western Blot (WB) — Western blot analysis of ACVR1 using a polyclonal antibody (Product # PA1-12641).

产品信息

PA1-12641

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

-

产品规格

种属反应

Chicken

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to the extracellular domain of chicken ALK2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

0.08% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_1069974

靶标信息

Activin A receptor, type I (ACVR1) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. ACVR1 signals a specific transcriptional response in concert with activin type II receptors. The ACVR1 gene encodes activin A type I receptor, which signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Activin receptor type I; Activin receptor type-1; Type I TGF B receptor

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基因别名: ACVR1

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UniProt ID: (Chicken) Q90ZK6

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Entrez Gene ID: (Chicken) 395246

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receptor signaling protein serine/threonine kinase activity transforming growth factor beta receptor activity, type I receptor signaling protein activity protein binding ATP binding protein homodimerization activity metal ion binding activin binding transforming growth factor beta binding

G1/S transition of mitotic cell cycle acute inflammatory response embryonic heart tube morphogenesis mitral valve morphogenesis atrial septum primum morphogenesis heart development positive regulation of alkaline phosphatase activity positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation cell migration peptidyl-threonine phosphorylation positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway activin receptor signaling pathway negative regulation of activin receptor signaling pathway intracellular signal transduction endothelial cell activation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter mesenchymal cell differentiation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation cardiac muscle cell fate commitment endocardial cushion cell fate commitment positive regulation of determination of dorsal identity negative regulation of extrinsic apoptotic signaling pathway