Invitrogen

ACVRL1 Polyclonal Antibody

查看其他24个ACVRL1抗体

产品信息

PA5-47010

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.1 µg/mL

-

免疫沉淀 (IP)

Assay-Dependent

-

产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Mouse myeloma cell line NS0-derived recombinant human ALK-1 Asp22-Gln118

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2608871

产品详细信息

In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse ALK-1 is observed and less than 1% cross-reactivity with recombinant human (rh) Activin RIA and rhActivin RIB is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

靶标信息

Activin A receptor type II-like 1 (ACVRL1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1, similar to other type 1 receptors, has a conserved serine-threonine kinase subdomain, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2. Mutations in ACVRL1 have been linked to Fibrodysplasia Ossificans Progressiva (FOP), a rare genetic disorder characterized by the formation of bone in muscles, tendons, and other connective tissues, as well as Epicanthus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: activin A receptor type II-like 1; activin A receptor type IL; activin A receptor, type II-like kinase 1; Activin receptor type-1-like; Activin receptor-like kinase 1; ALK-1; Serine/threonine-protein kinase receptor R3; SKR3; TGF-B superfamily receptor type I; TSR-I

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基因别名: ACVRL1; ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I

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UniProt ID: (Human) P37023

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Entrez Gene ID: (Human) 94

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protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I protein binding ATP binding activin receptor activity, type I protein kinase binding SMAD binding metal ion binding activin binding transforming growth factor beta binding BMP receptor activity serine/threonine protein kinase receptor

angiogenesis in utero embryonic development regulation of endothelial cell proliferation negative regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel maturation blood vessel remodeling blood vessel endothelial cell proliferation involved in sprouting angiogenesis endocardial cushion morphogenesis regulation of DNA replication regulation of transcription, DNA-templated protein phosphorylation negative regulation of cell adhesion signal transduction transforming growth factor beta receptor signaling pathway blood circulation regulation of blood pressure negative regulation of cell proliferation negative regulation of endothelial cell migration negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation signal transduction by protein phosphorylation negative regulation of cell growth negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway positive regulation of chondrocyte differentiation activin receptor signaling pathway wound healing, spreading of epidermal cells dorsal aorta morphogenesis regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration negative regulation of endothelial cell differentiation positive regulation of endothelial cell differentiation positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter protein heterooligomerization negative regulation of focal adhesion assembly lymphatic endothelial cell differentiation artery development venous blood vessel development endothelial tube morphogenesis retina vasculature development in camera-type eye cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus endocardial cushion to mesenchymal transition negative regulation of DNA biosynthetic process