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PA1-1742 detects ADAMTS5 in human samples.
PA1-1742 has been successfully used in Western blot procedures. In Western blot analysis of JJ012 cells this antibody detects a ~64 kDa protein representing ADAMTS5.
The PA1-1742 immunogen is a synthetic peptide corresponding to residues C I(442) L T S I D A S K P(451) of human ADAMTS5.
ADAMTS5, also known as Implantin or Aggrecanase 2, is a member of the larger family of ADAMs (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS5 (A Disintegrin And Metalloproteinase with Thrombospondin-5 motif) was first described as ADAMTS5, a protein elevated in mice during the peri-implantion period. At the same time, another group identified Aggrecanase 11, a protein elevated in arthritic synovium. The name was later changed to ADAMTS5. ADAMTS5 is expressed in human and mouse. It has been found in heart, lung, cervix, uterus, ovary, brain, cartilage, and numerous other tissues, as well as chondroblastoma cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM; ADAM-TS 11; ADAM-TS 5; ADAMs; ADMP-2; Aggrecanase 2; Aggrecanase-2; metalloendopeptidases
基因别名: ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS11; ADAMTS5; ADMP-2; ADMP2
UniProt ID: (Human) Q9UNA0
Entrez Gene ID: (Human) 11096