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产品信息
H00000148-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
4C7
抗原
ADRA1A (NP_150646, 1 a.a. approximately 27 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MVFLSGNASD SSNCTQPPAP VNISKAI
靶标信息
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. A1AR subtypes are found in numerous tissues and have been shown to be involved in the regulation of blood pressure due to changes in vascular tone and cardiac output. Effects on uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70), proto-oncogene expression, and mitogenesis have been linked to A1AR activation. Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus by activating alpha-1 AR which may indirectly suppress the release of luteinizing hormone (LH), the androgens, estrogen, and progesterone.
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生物信息学
蛋白别名: ADA1; adrenergic, alpha-1A-, receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; Alpha1C-AR; G protein coupled receptor
基因别名: ADRA1A; ADRA1C; ADRA1L1; ALPHA1AAR
UniProt ID: (Human) P35348
Entrez Gene ID: (Human) 148
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
positive regulation of systemic arterial blood pressure
apoptotic process
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
adult heart development
aging
negative regulation of cell proliferation
response to hormone
cell growth
positive regulation of synaptic transmission, GABAergic
negative regulation of Rho protein signal transduction
organ growth
intracellular signal transduction
response to drug
positive regulation of MAPK cascade
positive regulation of action potential
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
micturition
calcium ion transport into cytosol
positive regulation of cardiac muscle contraction
positive regulation of ERK1 and ERK2 cascade
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of protein kinase C signaling
pilomotor reflex
