Invitrogen

ADSL Polyclonal Antibody

ADSL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ADSL Antibody (PA5-29964) in IHC (P)

ADSL Polyclonal Antibody detects ADSL protein at cytosol on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. ADSL Polyclonal Antibody (Product # PA5-29964) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

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产品信息

PA5-29964

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 189 and 466 of Human ASL

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.34 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2547438

产品详细信息

Recommended positive controls: A431, H1299, HeLa, HepG2.

Predicted reactivity: Mouse (97%), Rat (95%), Zebrafish (84%), Xenopus laevis (90%), Pig (97%), Chicken (91%), Chimpanzee (98%), Bovine (95%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。