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产品信息
PA5-97439
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Adenylosuccinate lyase protein (1-310AA)
偶联物
形式
Liquid
浓度
0.47 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2812056
靶标信息
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
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生物信息学
蛋白别名: Adenylosuccinase; Adenylosuccinate lyase; adenylosuccinate lyase 1; ADSL; ASase; ASL
基因别名: Adl; ADSL; AMPS; ASASE; ASL
UniProt ID: (Human) P30566, (Mouse) P54822
Entrez Gene ID: (Human) 158, (Mouse) 11564
purine nucleotide biosynthetic process
AMP biosynthetic process
'de novo' IMP biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
'de novo' AMP biosynthetic process
protein tetramerization
purine nucleotide metabolic process
response to nutrient
metabolic process
aerobic respiration
purine ribonucleotide biosynthetic process
ribonucleoside monophosphate biosynthetic process
