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AGL Antibody (PA5-12142) in ICC/IF
Immunocytochemistry analysis of AGL in HepG2 cells. Samples were incubated with AGL polyclonal antibody (Product # PA5-12142). Expression of myc-GS causes wild type but not the CBD mutant of AGL to aggregate around the PAS-stain-positive inclusions. Cells were transfected with either HA-tagged wild-type AGL (HA-AGL) or HA-AGL CBD. Cells were fixed in formalin and processed for IF using anti-HA (green) and anti-myc (red) antibodies. White arrows indicate colocalization of HA-AGL and myc-GS.
产品信息
PA5-12142
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1479-1510 amino acids from the C-terminal region of human AGL
偶联物
形式
Liquid
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2224811
靶标信息
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 1-Apr; 4-alpha-glucanotransferase; 4-glucantransferase; amylo-1, 6-glucosidase, 4-alpha-glucanotransferase; Amylo-1,6-glucosidase; amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferaseprovided; Amylo-alpha-1,6-glucosidase; Dextrin 6-alpha-D-glucosidase; Glycogen debrancher; Glycogen debranching enzyme; glycogen debranching protein; Oligo-1; Oligo-1,4-1,4-glucantransferase
基因别名: AGL; GDE
UniProt ID: (Human) P35573
Entrez Gene ID: (Human) 178
