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AGR2 Antibody (720305) in ICC/IF
For immunofluorescence analysis, A549 cells were fixed and permeabilized for detection of endogenous Anterior gradient homlog-2 using Anti- AGR2 Rabbit Polyclonal Antibody (Product # 720305, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of AGR2 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product ... View More
产品信息
720305
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptides corresponding to Human AGR2 (31-44, 164-175)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 30% glycerol, 0.1% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2633250
产品详细信息
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Dog, Cat and Bovine
靶标信息
AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AG-2; anterior gradient 2 homolog; anterior gradient homolog 2; Anterior gradient protein 2 homolog; epididymis secretory protein Li 116; HPC8; protein disulfide isomerase family A, member 17; Protein Gob-4; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog
基因别名: AG2; AGR2; Agr2h; GOB-4; Gob4; HAG-2; HEL-S-116; mAG-2; PDIA17; UNQ515/PRO1030; XAG-2
UniProt ID: (Human) O95994, (Mouse) O88312
Entrez Gene ID: (Human) 10551, (Mouse) 23795, (Rat) 298961
positive regulation of gene expression
positive regulation of cell-substrate adhesion
response to endoplasmic reticulum stress
positive regulation of epidermal growth factor receptor signaling pathway
digestive tract morphogenesis
positive regulation of developmental growth
lung goblet cell differentiation
negative regulation of cell death
mucus secretion
positive regulation of establishment of protein localization to plasma membrane
positive regulation of IRE1-mediated unfolded protein response
positive regulation of PERK-mediated unfolded protein response
biological_process
