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AIFM3 Antibody (PA5-97129) in IHC (P)
Immunohistochemistry analysis of AIFM3 in paraffin-embedded human liver cancer. Samples were incubated with AIFM3 Polyclonal antibody (Product # PA5-97129) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-97129
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human AIFM3 (NP_0010180701)
偶联物
形式
Liquid
浓度
0.74 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808931
产品详细信息
Immunogen sequence: MGGCFSKPKP VELKIEVVLP EKERGKEELS ASGKGSPRAY QGNGTARHFH TEERLSTPHP YPSPQDCVEA AVCHVKDLEN GQMREVELGW GKVLLVKDNG EFHALGHKCP HYGAPLVKGV LSRGRVRCPW HGACFNISTG DLEDFPGLDS LHKFQVKIEK EKVYVRASKQ ALQLQRRTKV MAKCISPSAG YSSSTNVLIV; Positive Samples: THP-1, HeLa; Cellular Location: Mitochondrion
靶标信息
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor, mitochondrion-associated, 3; Apoptosis-inducing factor-like protein
基因别名: 2810401C16Rik; AI840249; AIFL; AIFM3; RGD1306028
UniProt ID: (Human) Q96NN9, (Mouse) Q3TY86
Entrez Gene ID: (Human) 150209, (Mouse) 72168, (Rat) 303786
oxidoreductase activity
metal ion binding
flavin adenine dinucleotide binding
2 iron, 2 sulfur cluster binding
N-ethylmaleimide reductase activity
reduced coenzyme F420 dehydrogenase activity
sulfur oxygenase reductase activity
malolactic enzyme activity
NADPH:sulfur oxidoreductase activity
iron-sulfur cluster binding
epoxyqueuosine reductase activity
oxidoreductase
