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Immunogen sequence: EHVLELENSK GPSLASLEGE EDKGKSSSSQ VVGPVQEEEY VAEKLPSRFI ESAHTELAKD DAAPAPPVAD AKAQDRGVEG ELGNEESLDR NEEGLDRNEE GLDRNEESLD RNEEGLDRNE EIKRAAFQII SQVISEATEQ V
Highest antigen sequence identity to the following orthologs: Mouse - 35%, Rat - 35%.
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: A kinase (PRKA) anchor protein 1; A-kinase anchor protein 1, mitochondrial; A-kinase anchor protein 149 kDa; AKAP 149; D-AKAP-1; Dual specificity A-kinase-anchoring protein 1; dual-specificity A-kinase anchoring protein 1; PRKA1; protein kinase A anchoring protein 1; Protein kinase A-anchoring protein 1; protein kinase A1; protein phosphatase 1, regulatory subunit 43; S-AKAP84; spermatid A-kinase; Spermatid A-kinase anchor protein 84; testicular secretory protein Li 5; tudor domain containing 17
基因别名: AKAP; AKAP1; AKAP121; AKAP149; AKAP84; D-AKAP1; PPP1R43; PRKA1; SAKAP84; TDRD17
UniProt ID: (Human) Q92667
Entrez Gene ID: (Human) 8165