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AKAP6 Antibody (PA5-88760) in WB
Western blot analysis of AKAP6 in extracts of various cell lines. Samples were incubated with AKAP6 Polyclonal antibody (Product # PA5-88760) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-88760
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human AKAP6 (NP_0042653)
偶联物
形式
Liquid
浓度
1.08 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805110
产品详细信息
Immunogen sequence: MLTMSVTLSP LRSQDLDPMA TDASPMAINM TPTVEQGEGE EAMKDMDSDQ QYEKPPPLHT GADWKIVLHL PEIETWLRMT SERVRDLTYS VQQDSDSKHV DVHLVQLKDI CEDISDHVEQ IHALLETEFS LKLLSYSVNV IVDIHAVQLL WHQLRVSVLV LRERILQGLQ DANGNYTRQT DILQAFSEET KEGRLDSLTE VDDSGQLTIK CSQNYLSLDC GITAFELSDY SPSEDLLSGL GDMTSSQVKT KPFDSWSYSE MEKEFPELIR; Positive Samples: U-87MG, SH-SY5Y; Cellular Location: Nucleus membrane, Sarcoplasmic reticulum
靶标信息
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A kinase (PRKA) anchor protein 6; A-kinase anchor protein 100 kDa; A-kinase anchor protein 6; AKAP 100; AKAP-6; mAKAP; PRKA6; protein kinase A anchoring protein 6; Protein kinase A-anchoring protein 6
基因别名: ADAP100; ADAP6; AKAP100; AKAP6; KIAA0311; mAKAP; PRKA6
UniProt ID: (Human) A7E2D4
Entrez Gene ID: (Human) 9472
action potential
protein targeting
regulation of protein kinase A signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
positive regulation of cell growth
negative regulation of cAMP biosynthetic process
positive regulation of protein phosphatase type 2B activity
intracellular signal transduction
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of NFAT protein import into nucleus
regulation of membrane repolarization
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of calcineurin-NFAT signaling cascade
cellular response to cAMP
cellular response to cytokine stimulus
positive regulation of potassium ion transmembrane transport
positive regulation of delayed rectifier potassium channel activity
