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产品信息
PA5-52103
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2637816
产品详细信息
Immunogen sequence: PEMEGDDNLG GEDKKETPEE VAADVLAEVI TAAVRAVDGE GAPAPESSGE PAEDEGPTDT AEAGSDPQAE QLLEEQVPCG TAHEKGVPKA RSEAAEAGNG AETMAAEAES AQTRVAPAPA AADAEVEQTD AESKDAVP
Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 58%.
靶标信息
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
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生物信息学
蛋白别名: A kinase (PRKA) anchor protein 8; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; AKAP 8; AKAP 95; AKAP-8; DKFZp586B1222
基因别名: AKAP 95; AKAP-8; AKAP-95; AKAP8; AKAP95
UniProt ID: (Human) O43823
Entrez Gene ID: (Human) 10270
transcription, DNA-templated
regulation of transcription, DNA-templated
mitotic nuclear division
mitotic chromosome condensation
signal transduction
protein transport
positive regulation of histone deacetylation
regulation of histone phosphorylation
cell cycle G2/M phase transition
innate immune response
