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AKR1C1 Antibody (H00001645-B01P) in WB
Western Blot analysis of AKR1C1 expression in transfected 293T cell line (H00001645-T01) by AKR1C1 MaxPab polyclonal antibody.
Lane 1: AKR1C1 transfected lysate(35.53 KDa).
Lane 2: Non-transfected lysate.
Lane 1: AKR1C1 transfected lysate(35.53 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00001645-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AKR1C1 (NP_001344.2, 1 a.a. approximately 323 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY
靶标信息
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; Chlordecone reductase homolog HAKRC; DD1; Dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; dihydrodiol dehydrogenase isoform DD1; HBAB; hepatic dihydrodiol dehydrogenase; High-affinity hepatic bile acid-binding protein; indanol dehydrogenase; RP11-69D4.1; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase
基因别名: 2-ALPHA-HSD; 20-ALPHA-HSD; AKR1C1; C9; DD1; DD1/DD2; DDH; DDH1; H-37; HAKRC; HBAB; MBAB
UniProt ID: (Human) Q04828
Entrez Gene ID: (Human) 1645
alditol:NADP+ 1-oxidoreductase activity
aldo-keto reductase (NADP) activity
protein binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
carboxylic acid binding
bile acid binding
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase (B-specific) activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity
oxidoreductase
reductase
metabolite interconversion enzyme
retinoid metabolic process
xenobiotic metabolic process
digestion
bile acid metabolic process
bile acid and bile salt transport
intestinal cholesterol absorption
epithelial cell differentiation
progesterone metabolic process
retinal metabolic process
cholesterol homeostasis
daunorubicin metabolic process
doxorubicin metabolic process
response to organophosphorus
protein homooligomerization
oxidation-reduction process
cellular response to jasmonic acid stimulus
