Invitrogen

AKR1C1 Polyclonal Antibody

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AKR1C1 Antibody (PA5-120192) in WB

Western blot analysis of AKR1C1 in extracts of various cell lines. Samples were incubated with AKR1C1 Polyclonal antibody (Product # PA5-120192) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

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产品信息

PA5-120192

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.22 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2913764

产品详细信息

Positive test controls include: HeLa, 22Rv1, U-87MG, Mouse liver. The target is usually found in the following locations: Cytoplasm.

Immunogen sequence: MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

靶标信息

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 17-beta-HSD 5; 17HSD type 5; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; aldo-keto reductase family 1, member C1 (aldehyde reductase); Chlordecone reductase homolog HAKRC; DD1; Dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; dihydrodiol dehydrogenase isoform DD1; Estradiol 17 beta-dehydrogenase 5; estradiol 17-beta-dehydrogenase (A-specific); HBAB; hepatic dihydrodiol dehydrogenase; High-affinity hepatic bile acid-binding protein; hydroxysteroid 17-beta dehydrogenase 5; indanol dehydrogenase; RP11-69D4.1; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase

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基因别名: 2-ALPHA-HSD; 20-ALPHA-HSD; 3alpha-HSD; AKR1C1; Akr1c6; C9; DD1; DD1/DD2; DDH; DDH1; H-37; HAKRC; HBAB; Hsd17b5; MBAB

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UniProt ID: (Human) Q04828, (Mouse) P70694

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Entrez Gene ID: (Human) 1645, (Mouse) 83702

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