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ALAS2 Antibody (PA5-143885) in ICC/IF
Immunocytochemistry analysis of ALAS2 in PC-3 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum. Samples were then incubated in ALAS2 Polyclonal antibody (Product # PA5-143885) using a dilution of 5 μg/mL. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropriate f... View More
产品信息
PA5-143885
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human ALAS2/ASB recombinant protein (Position: M1-D190).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3075099
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
靶标信息
ALAS2 specifies an erythroid-specific mitochondrially located enzyme. It catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia.The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5-aminolevulinic acid synthase 2; ALAS-E; Aminolevulinate synthase 2, delta; aminolevulinate, delta-, synthase 2; aminolevulinic acid synthase 2, erythroid; Delta-ALA synthase 2; delta-ALA synthetase; Delta-aminolevulinate synthase 2; erythroid-specific ALAS; erythroid-specific delta-aminolevulinate synthase ALAS-E; PRO2399; RP5-884M20.1
基因别名: ALAS; Alas-2; ALAS-E; ALAS2; ALASE; ANH1; ASB; SIDBA1; XLDPP; XLEPP; XLSA
UniProt ID: (Human) P22557, (Rat) Q63147, (Mouse) P08680
Entrez Gene ID: (Human) 212, (Rat) 25748, (Mouse) 11656
response to hypoxia
protoporphyrinogen IX biosynthetic process
heme biosynthetic process
cellular iron ion homeostasis
erythrocyte differentiation
oxygen homeostasis
hemoglobin biosynthetic process
female pregnancy
lactation
response to lead ion
response to drug
porphyrin-containing compound metabolic process
metabolic process
biosynthetic process
tetrapyrrole biosynthetic process
