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ALDH4A1 Antibody (PA5-102639) in IHC (P)
Immunohistochemistry analysis of ALDH4A1 in human kidney cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ALDH4A1 polyclonal antibody (Product # PA5-102639) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102639
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ALDH4A1(Accession P30038), corresponding to amino acid residues N499-E549.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852036
产品详细信息
Antibody detects endogenous levels of total ALDH4A1.
靶标信息
ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aldehyde dehydrogenase 4 family, member A1; Aldehyde dehydrogenase family 4 member A1; Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; L-glutamate gamma-semialdehyde dehydrogenase; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C dehydrogenase; RP11-128M10.1
基因别名: A930035F14Rik; Ahd-1; Ahd1; ALDH4; ALDH4A1; Aldh5a1; E330022C09; P5CD; P5CDH; P5cdhl; P5cdhs; Ssdh1
UniProt ID: (Human) P30038, (Mouse) Q8CHT0
Entrez Gene ID: (Human) 8659, (Rat) 641316, (Mouse) 212647
1-pyrroline-5-carboxylate dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
electron carrier activity
identical protein binding
structural molecule activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
