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产品信息
PA5-29096
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 85 and 324 of Human ALDH5A1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546572
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain, A549.
Predicted reactivity: Mouse (84%), Rat (84%), Pig (85%), Chimpanzee (92%), Bovine (86%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aldehyde dehydrogenase 1, mitochondrial; Aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase; Succinate-semialdehyde dehydrogenase, mitochondrial
基因别名: 6330403E24Rik; Ahd-1; Ahd1; ALDH5A1; D630032B01Rik; OTTMUSG00000000613; SSADH; SSDH; Ssdh1
UniProt ID: (Human) P51649, (Mouse) Q8BWF0
Entrez Gene ID: (Human) 7915, (Mouse) 214579
aldehyde dehydrogenase (NAD) activity
succinate-semialdehyde dehydrogenase (NAD+) activity
succinate-semialdehyde dehydrogenase [NAD(P)+] activity
carboxylic acid binding
protein homodimerization activity
NAD binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
glucose metabolic process
acetate metabolic process
succinate metabolic process
glutamate metabolic process
glutamine metabolic process
glycerophospholipid metabolic process
glucosylceramide metabolic process
galactosylceramide metabolic process
glutathione metabolic process
central nervous system development
gamma-aminobutyric acid catabolic process
post-embryonic development
respiratory electron transport chain
neurotransmitter catabolic process
short-chain fatty acid metabolic process
protein homotetramerization
metabolic process
gamma-aminobutyric acid metabolic process
oxidation-reduction process
