Invitrogen

ALOX12B Polyclonal Antibody

View all (4) ALOX12B antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-116671

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALOX12B (NP_0011301)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.7 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2901302

Product Specific Information

Positive Samples: A-431, Mouse spleen, Rat testis

Immunogen sequence: MATYKVRVAT GTDLLSGTRD SISLTIVGTQ GESHKQLLNH FGRDFATGAV GQYTVQCPQD LGELIIIRLH KERYAFFPKD PWYCNYVQIC APNGRIYHFP AYQWMDGYET LALREATGKT TADDSLPVLL EHRKEEIRAK QDFYHWRVFL PGLPSYVHIP SYRPPVRRHR NPNRPEWNGY IPGFPILINF KATKFLNLNL RYSFLKTASF FVRLGPMALA FKVRGLLDCK HSWKRLKDIR KIFPGKKSVV

Target Information

This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 12R-lipoxygenase; 12R-LOX; alox12b {ECO:0000312|RGD:1305330}; Arachidonate 12-lipoxygenase, 12R-type; e-LOX 2; Epidermis-type lipoxygenase 12; Epidermis-type lipoxygenase 2

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Gene Aliases: 12R-LOX; ALOX12B; Aloxe2; ARCI2; e-LOX2

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UniProt ID: (Human) O75342, (Mouse) O70582, (Rat) Q2KMM4

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Entrez Gene ID: (Human) 242, (Mouse) 11686, (Rat) 287425

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Function(s)
arachidonate 12-lipoxygenase activity iron ion binding protein binding oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen linoleate 9S-lipoxygenase activity oxidoreductase activity 2,3-dihydroxy DDT 1,2-dioxygenase activity phenanthrene dioxygenase activity 2,2',3-trihydroxybiphenyl dioxygenase activity 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity protocatechuate 3,4-dioxygenase type II activity 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity carbazole 1,9a-dioxygenase activity dihydroxydibenzothiophene dioxygenase activity 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity styrene dioxygenase activity 3,4-dihydroxyphenanthrene dioxygenase activity hydroquinone 1,2-dioxygenase activity p-cumate 2,3-dioxygenase activity 2,3-dihydroxy-p-cumate dioxygenase activity 3,5-dichlorocatechol 1,2-dioxygenase activity 2-aminophenol 1,6-dioxygenase activity 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity chlorocatechol 1,2-dioxygenase activity catechol dioxygenase activity dihydroxyfluorene dioxygenase activity 5-aminosalicylate dioxygenase activity 3-hydroxy-2-naphthoate 2,3-dioxygenase activity benzo(a)pyrene 11,12-dioxygenase activity benzo(a)pyrene 4,5-dioxygenase activity 4,5-dihydroxybenzo(a)pyrene dioxygenase activity benzo(a)pyrene 9,10-dioxygenase activity 9,10-dihydroxybenzo(a)pyrene dioxygenase activity benzo(a)pyrene 7,8-dioxygenase activity 7,8-dihydroxy benzo(a)pyrene dioxygenase activity 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity 2-mercaptobenzothiazole dioxygenase activity pyridine-3,4-diol dioxygenase activity pyrene dioxygenase activity 4,5-dihydroxypyrene dioxygenase activity phenanthrene-4-carboxylate dioxygenase activity tetrachlorobenzene dioxygenase activity 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity 2,3-dihydroxydiphenyl ether dioxygenase activity diphenyl ether 1,2-dioxygenase activity arachidonate 8(S)-lipoxygenase activity metal ion binding 4-hydroxycatechol 1,2-dioxygenase activity dioxygenase activity molecular_function oxygenase
Process(es)
protein lipidation sphingolipid metabolic process positive regulation of gene expression arachidonic acid metabolic process lipoxygenase pathway positive regulation of MAPK cascade linoleic acid metabolic process ceramide biosynthetic process hepoxilin biosynthetic process oxidation-reduction process establishment of skin barrier positive regulation of mucus secretion lipid metabolic process fatty acid metabolic process bicellular tight junction assembly biological_process
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