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ALOXE3 Antibody (PA5-23953) in IHC (P)
Immunohistochemistry analysis of ALOXE3 in paraffin-embedded Human breast tissue. Samples were incubated with ALOXE3 polyclonal antibody (Product # PA5-23953) using a dilution of 1:500 for 1 hour at room temperature followed by an undiluted biotinylated CRF Anti-Polyvalent HRP Polymer antibody. Tissue was fixed with formaldehyde at room temperature, antigen retrieval was by heat mediation with a EDTA buffer... View More
产品信息
PA5-23953
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 223-252 amino acids from the central region of human ALOXE3
偶联物
形式
Liquid
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2541453
靶标信息
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: e-LOX-3; epidermal lipoxygenase; Epidermal LOX-3; Epidermis-type lipoxygenase 3; Hydroperoxide isomerase ALOXE3; Hydroperoxy dehydratase ALOXE3; Hydroperoxy icosatetraenoate dehydratase; Hydroperoxy icosatetraenoate isomerase
基因别名: ALOXE3; ARCI3; E-LOX; eLOX-3; eLOX3
UniProt ID: (Human) Q9BYJ1
Entrez Gene ID: (Human) 59344
sphingolipid metabolic process
sensory perception of pain
arachidonic acid metabolic process
lipoxygenase pathway
peroxisome proliferator activated receptor signaling pathway
linoleic acid metabolic process
fat cell differentiation
ceramide biosynthetic process
hepoxilin biosynthetic process
oxidation-reduction process
establishment of skin barrier
