Invitrogen

ALP Polyclonal Antibody

ALP Antibody in Immunocytochemistry (ICC/IF)

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ALP Antibody (PA5-106391) in ICC/IF

Immunofluorescent analysis of ALP in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and ALP polyclonal antibody (Product # PA5-106391) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).

ALP Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-106391

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human ASRGL1(Accession Q7L266), corresponding to amino acid residues G195-E245.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2854065

产品详细信息

Antibody detects endogenous levels of total ASRGL1.

靶标信息

ALP is found in a variety of tumors but only occasionally in normal tissues. Ovarian cancers are highly positive. ALP is further found in brain tumors, some colonic cancers, some lung cancers, some prostate cancers, uterine cancers, some breast cancers and some thyroid cancers. It was not found in serum.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Long non-coding RNA telomerase RNA elements improve glucocorticoid-induced osteoporosis by EZH2 to regulate DKK1.

International journal of rheumatic diseases

Hu H,Guo X,Mu T,Song H

Published figure using ALP polyclonal antibody (Product # PA5-106391) in Western Blot

Sat Apr 01 00:00:00 UTC 2023

Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice.

Journal of orthopaedic translation

Qin L,Chen Z,Yang D,He T,Xu Z,Zhang P,Chen D,Yi W,Xiao G

PA5-106391 was used in Immunocytochemistry to demonstrate the essential roles of osteocyte β3 integrin in regulating bone mass and mechanotransduction.

Mon May 01 00:00:00 UTC 2023

Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms.

Signal transduction and targeted therapy

Jia N,Gao Y,Li M,Liang Y,Li Y,Lin Y,Huang S,Lin Q,Sun X,He Q,Yao Y,Zhang B,Zhang Z,Zhang L

PA5-106391 was used in Immunohistochemistry to develop a targeting delivery system that remarkably improved the anti-RA efficiency of RBA, but also identified a potential molecular target to reversely reprogram macrophages though energy metabolism regulation.

Fri Jul 28 00:00:00 UTC 2023

Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking.

Nature communications

Wang T,Bai J,Lu M,Huang C,Geng D,Chen G,Wang L,Qi J,Cui W,Deng L

PA5-106391 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that the dual-effect coating can be utilized to synergistically modulate the osteoimmune microenvironment at the bone-implant interface, enhancing bone regeneration for successful implantation.

Mon Jan 10 00:00:00 UTC 2022

生物信息学

蛋白别名: asparaginase-like 1; asparaginase-like 1 protein; Asparaginase-like protein 1; Asparaginase-like sperm autoantigen; Beta-aspartyl-peptidase; FLJ22316; Glial asparaginase; Isoaspartyl dipeptidase; Isoaspartyl peptidase/L-asparaginase; L-asparaginase; L-asparagine amidohydrolase; testis secretory sperm-binding protein Li 242mP

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基因别名: 2410004D18Rik; ALP; ALP1; ASRGL1; AU040643; AW060375; CRASH; Gliap; Hiob; Hiob2

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UniProt ID: (Human) Q7L266, (Rat) Q8VI04, (Mouse) Q8C0M9

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Entrez Gene ID: (Human) 80150, (Rat) 246307, (Mouse) 66514

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功能

N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity asparaginase activity beta-aspartyl-peptidase activity peptidase activity hydrolase activity protease

参与通路

proteolysis L-phenylalanine catabolic process asparagine catabolic process via L-aspartate