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ALPK2 Antibody (PA5-104538) in IHC (P)
Immunohistochemistry analysis of ALPK2 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ALPK2 polyclonal antibody (Product # PA5-104538) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104538
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ALPK2(Accession Q86TB3), corresponding to amino acid residues L1742-I1792.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2853838
Product Specific Information
Antibody detects endogenous levels of total ALPK2.
Target Information
Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (PubMed:10021370). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (PubMed:29888752). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-kinase 2; Alpha-protein kinase 2; alpk2; heart alpha-kinase; Heart alpha-protein kinase; RNF18
Gene Aliases: ALPK2; Gm549; HAK; RGD1564431
UniProt ID: (Human) Q86TB3, (Mouse) Q91ZB0
Entrez Gene ID: (Human) 115701, (Mouse) 225638, (Rat) 498875
protein serine/threonine kinase activity
ATP binding
molecular_function
transmembrane receptor protein serine/threonine kinase activity
3-phosphoinositide-dependent protein kinase activity
DNA-dependent protein kinase activity
AMP-activated protein kinase activity
cyclic nucleotide-dependent protein kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
calcium-dependent protein kinase C activity
receptor signaling protein serine/threonine kinase activity
NF-kappaB-inducing kinase activity
JUN kinase activity
JUN kinase kinase kinase activity
MAP kinase kinase activity
MAP kinase kinase kinase activity
ribosomal protein S6 kinase activity
MAP kinase kinase kinase kinase activity
JUN kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
SAP kinase activity
transmembrane receptor protein kinase activity
cyclin-dependent protein kinase activating kinase activity
GTP-dependent protein kinase activity
non-receptor serine/threonine protein kinase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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