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产品信息
PA5-88053
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1109-1208 of human Ambra1 (NP_060219.2).
偶联物
形式
Liquid
浓度
1.87 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804619
产品详细信息
Positive Samples: U-87MG, HeLa, Jurkat, MCF7; Cellular Location: Cytoplasmic vesicle, autophagosome
Immunogen Sequence: GAAHTSSPQP STSRGLLPEA GQLAERGLSP RTASWDQPGT PGREPTQPTL PSSSPVPIPV SLPSAEGPTL HCELTNNNHL LDGGSSRGDA AGPRGEPRNR
靶标信息
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activating molecule in Beclin1-regulated autophagy; Activating molecule in BECN1-regulated autophagy protein 1; ischemia related factor NYW-1
基因别名: 2310079H06Rik; A130023A14; AA474864; Ambra1; AV021921; D030051N19Rik; Kiaa1736; mKIAA1736; Nyw1
UniProt ID: (Mouse) A2AH22
Entrez Gene ID: (Rat) 59319, (Mouse) 228361
autophagy
negative regulation of cell proliferation
neural tube development
negative regulation of neuron apoptotic process
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of mitophagy
regulation of autophagosome assembly
multicellular organism development
nervous system development
embryo development
cell differentiation
mitophagy in response to mitochondrial depolarization
