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AMFR Antibody (PA5-102892) in IHC (P)
Immunohistochemistry analysis of AMFR in mouse heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with AMFR polyclonal antibody (Product # PA5-102892) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102892
产品规格
种属反应
Human,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human AMFR(Accession Q9UKV5), corresponding to amino acid residues R484-T534.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852274
产品详细信息
Antibody detects endogenous levels of total AMFR.
靶标信息
Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMF receptor; Autocrine motility factor receptor; autocrine motility factor receptor, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase AMFR; gp78; RING finger protein 45
基因别名: AMFR; GP78; RNF45
UniProt ID: (Human) Q9UKV5
Entrez Gene ID: (Human) 267, (Rat) 361367
ubiquitin-protein transferase activity
receptor activity
protein binding
zinc ion binding
ligase activity
protein binding, bridging
ubiquitin-ubiquitin ligase activity
chaperone binding
ubiquitin protein ligase activity
ubiquitin protein ligase activity involved in ERAD pathway
BAT3 complex binding
ubiquitin-specific protease binding
molecular_function
ubiquitin-protein ligase
protein modifying enzyme
protein polyubiquitination
ubiquitin-dependent protein catabolic process
movement of cell or subcellular component
signal transduction
aging
learning or memory
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
positive regulation of protein binding
ERAD pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
protein oligomerization
protein autoubiquitination
protein K48-linked ubiquitination
