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AMHR2 Antibody (PA5-119934) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human lung carcinoma tissue using AMHR2 Polyclonal Antibody (Product # PA5-119934). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the AMHR2 antibody at a dilution... View More
产品信息
PA5-119934
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within human AMHR2 aa 350-573/573
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2913506
产品详细信息
Positive Control: MCF-7 cell lysate, Hela cell lysate, 293 cell lysate, mouse lung tissue lysate, MCF-7, rat uterus tissue, human lung carcinoma tissue, human uterus tissue.
Subcellular Location: Membrane.
靶标信息
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth; anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AMH type II receptor; Anti-Muellerian hormone type II receptor; Anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor type 11 SV1; anti-Mullerian hormone receptor type II; anti-Mullerian hormone receptor, type II; anti-Mullerian hormone type 2 receptor; anti-Mullerian hormone type 2 receptor delta 2; anti-Mullerian hormone type 2 receptor delta 9/10; C14; MIS type II receptor; MISRII; MRII; Muellerian inhibiting substance type II receptor; Mullerian inhibiting substance type II receptor
基因别名: AMHR; AMHR2; Misiir; MISR2; MISRII; MRII
UniProt ID: (Human) E9PGD2, (Mouse) Q8K592, (Rat) Q62893
Entrez Gene ID: (Human) 269, (Mouse) 110542, (Rat) 29530
receptor signaling protein serine/threonine kinase activity
receptor activity
transforming growth factor beta receptor activity, type II
protein binding
ATP binding
hormone binding
metal ion binding
anti-Mullerian hormone receptor activity
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
serine/threonine protein kinase receptor
Mullerian duct regression
signal transduction
transforming growth factor beta receptor signaling pathway
sex differentiation
male gonad development
female gonad development
signal transduction by protein phosphorylation
negative regulation of anti-Mullerian hormone signaling pathway
anti-Mullerian hormone signaling pathway
protein phosphorylation
transmembrane receptor protein serine/threonine kinase signaling pathway
G-protein coupled receptor signaling pathway
phosphorylation
