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产品信息
MA5-24138
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
401901
抗原
Mouse myeloma cell line NS0-derived recombinant human AMICA/JAML Leu20-Leu275
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2606935
产品详细信息
In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse AMICA is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Junctional adhesion molecule-like
基因别名: AMICA; AMICA1; CREA7-1; CREA7-4; Gm638; JAML; UNQ722/PRO1387
UniProt ID: (Human) Q86YT9
Entrez Gene ID: (Human) 120425
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
neutrophil chemotaxis
monocyte extravasation
gamma-delta T cell activation
regulation of immune response
leukocyte migration
positive regulation of epithelial cell proliferation involved in wound healing
neutrophil extravasation
