Invitrogen

AMOTL1 Polyclonal Antibody

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AMOTL1 Antibody (PA5-42267) in WB

Western blot analysis of human 293T cell lysate using an anti-AMOTL1 polyclonal antibody (Product # PA5-42267).

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产品信息

PA5-42267

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.2-1 µg/mL

查看3篇已发表文章 3篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the N-terminal of human AMOTL1 (aa 144-193).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2606805

产品详细信息

Peptide sequence: LTQEDPQMVY QSARQEPQGQ EHQVDNTVME KQVRSTQPQQ NNEELPTYEE

Sequence homology: Cow: 93%; Dog: 79%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%

靶标信息

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines.

iScience

Mygland L,Brinch SA,Strand MF,Olsen PA,Aizenshtadt A,Lund K,Solberg NT,Lycke M,Thorvaldsen TE,Espada S,Misaghian D,Page CM,Agafonov O,Nygård S,Chi NW,Lin E,Tan J,Yu Y,Costa M,Krauss S,Waaler J

Published figure using AMOTL1 polyclonal antibody (Product # PA5-42267) in Western Blot

Fri Jul 23 00:00:00 UTC 2021

A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation.

Cancers

Kierulf-Vieira KS,Sandberg CJ,Waaler J,Lund K,Skaga E,Saberniak BM,Panagopoulos I,Brandal P,Krauss S,Langmoen IA,Vik-Mo EO

PA5-42267 was used in Western Blotting to suggest that tankyrase inhibition may serve as a supplement to current GBM therapy, although more work is needed to determine the exact downstream mechanisms involved.

Fri Jun 19 00:00:00 UTC 2020

A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation.

Cancers

Kierulf-Vieira KS,Sandberg CJ,Waaler J,Lund K,Skaga E,Saberniak BM,Panagopoulos I,Brandal P,Krauss S,Langmoen IA,Vik-Mo EO

Fri Jun 19 00:00:00 UTC 2020

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Communications biology

Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S

PA5-42267 was used in Western Blotting to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.