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产品信息
PA5-55316
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2637916
产品详细信息
Immunogen sequence: SETSSTKLSH IDEYISSSPT YQTVPDFQRV QITGDYASGV TVEDFEIVCK GLYRALCIRE KYMQKSFQRF PKTPSKYLRN IDGEAWVANE
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
靶标信息
AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP, liberating ammonia. There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions and in capillaries. This protein is the predominant member of AMPD multi-gene family and is considered as the sensor of the cell’s changing energy requirements. AMPD1 deficiency causes irregular muscle metabolism due to lower rate of ATP degradation, phosphocreatine hydrolysis and accumulation of lactic acid. Mutated AMPD1 expression has been detected in neuromuscular disorders, exercise-induced skeletal muscle myopathies and congestive heart failures due to coronary artery diseases.
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生物信息学
蛋白别名: adenosine monophosphate deaminase 1 (isoform M); adenosine monophosphate deaminase-1 (muscle); AMP deaminase 1; AMP deaminase isoform M; AMPD; Myoadenylate deaminase; RP5-1000E10.1; skeletal muscle AMPD
基因别名: AMPD1; MAD; MADA; MMDD
UniProt ID: (Human) P23109
Entrez Gene ID: (Human) 270
