Invitrogen

AMPK alpha-1,2 Polyclonal Antibody

AMPK alpha-1,2 Antibody in Immunocytochemistry (ICC/IF)

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AMPK alpha-1,2 Antibody (PA5-116552) in ICC/IF

Immunofluorescence analysis of AMPK alpha-1,2 in NIH/3T3 cells. Samples were incubated with AMPK alpha-1,2 Polyclonal antibody (Product # PA5-116552) using a dilution of 1:20 (40x lens). Blue: DAPI for nuclear staining.

AMPK alpha-1,2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

AMPK alpha-1,2 Antibody in Western Blot (WB)

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产品信息

PA5-116552

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:50-1:200

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 13-300 of human PRKAA1/PRKAA2 (NP_0062425)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.35 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

AB_2901183

产品详细信息

Positive Samples: HeLa, NIH/3T3, PC-12, Mouse brain, Rat heart

Immunogen sequence: AEKQKHDGRV KIGHYILGDT LGVGTFGKVK VGKHELTGHK VAVKILNRQK IRSLDVVGKI RREIQNLKLF RHPHIIKLYQ VISTPSDIFM VMEYVSGGEL FDYICKNGRL DEKESRRLFQ QILSGVDYCH RHMVVHRDLK PENVLLDAHM NAKIADFGLS NMMSDGEFLR TSCGSPNYAA PEVISGRLYA GPEVDIWSSG VILYALLCGT LPFDDDHVPT LFKKICDGIF YTPQYLNPSV ISLLKHMLQV DPMKRATIKD IREHEWFKQD LPKYLFPEDP SYSSTMID

靶标信息

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase catalytic subunit alpha-2; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; 5'-AMP-activated protein kinase, catalytic alpha-2 chain; AAPK2; ACACA kinase; Acetyl-CoA carboxylase kinase; AMP -activate kinase alpha 1 subunit; AMP-activated protein kinase; AMP-activated protein kinase alpha-2 subunit variant 2; AMP-activated protein kinase alpha-2 subunit variant 3; AMP-activated protein kinase alpha-2 variant B; AMP-activated protein kinase, alpha 1 catalytic subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK alpha 1; AMPK alpha 2; AMPK alpha-1 chain; AMPK alpha-2 chain; AMPK subunit alpha-1; AMPK subunit alpha-2; AMPK-alpha-1 chain; AMPK-alpha-2 chain; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; pAMPK; prkaa2; protein kinase, AMP-activated, alpha 1 catalytic subunit; protein kinase, AMP-activated, alpha 2 catalytic subunit; Tau-protein kinase PRKAA1

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基因别名: 2310008I11Rik; A830082D05; AI194361; AI450832; AL024255; AMPK; AMPK1; AMPK2; AMPKa1; AMPKa2; AMPKalpha1; AMPKalpha2; C130083N04Rik; PRKAA; PRKAA1; PRKAA2