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ANKLE2 Antibody (PA5-109389) in IHC (P)
Immunohistochemistry analysis of ANKLE2 in paraffin-embedded human lung cancer. Samples were incubated with ANKLE2 Polyclonal antibody (Product # PA5-109389) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-109389
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 350-450 of human ANKLE2 (NP_055929.1).
偶联物
形式
Liquid
浓度
1.05 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2854800
产品详细信息
Immunogen sequence: CRYNVMHVAA KENQASICQL TLDVLENPDF MRLMYPDDDE AMLQKRIRYV VDLYLNTPDK MGYDTPLHFA CKFGNADVVN VLSSHHLIVK NSRNKYDKTP E
靶标信息
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ankyrin repeat and LEM domain-containing protein 2; LEM domain containing 7; LEM domain-containing protein 4; liver regeneration-related protein LRRG057
基因别名: 1110001J12Rik; Ab2-034; AI661024; ANKLE2; D5Ertd585e; KIAA0692; LEM4; LEMD7; MCPH16; RGD1310191
UniProt ID: (Human) Q86XL3, (Mouse) Q6P1H6
Entrez Gene ID: (Human) 23141, (Mouse) 71782, (Rat) 360829
mitotic nuclear division
mitotic nuclear envelope reassembly
central nervous system development
regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
negative regulation of phosphorylation
negative regulation of apoptotic process
regulation of catalytic activity
cell division
cell cycle
