Invitrogen

AOX1 Polyclonal Antibody

AOX1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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AOX1 Antibody (PA5-59107) in IHC (P)

Immunohistochemical analysis of AOX1 in human lymph node using AOX1 Polyclonal Antibody (Product # PA5-59107) shows no cytoplasmic positivity in non-germinal center cells as expected.

AOX1 Antibody in Immunohistochemistry (IHC)

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AOX1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of AOX1 demonstrates antibody specificity. Immunohistochemical analysis of AOX1 using anti-AOX1 Polyclonal Antibody (Product # PA5-59107), shows significant staining of AOX1 in human liver and shows minimal or weak staining in human cerebral cortex tissues. The relative expression levels of AOX1 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-59107

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human AOX1. Recombinant protein control fragment (Product #RP-96096).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2638039

产品详细信息

Immunogen sequence: GVVDIMTAEH LSDVNSFCFF TEAEKFLATD KVFCVGQLVC AVLADSEVQA KRAAKRVKIV YQDLEPLILT IEESIQHNSS FKPERKLEYG NVDE

Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 70%.

靶标信息

AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of a variety of aldehydes, leading to the production of hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), an autosomal dominant neurodegenerative disorder characterized by the death of motor neurons in the spinal cord, brain and brainstem. Significantly, AOX1 is highly expressed in the ventral horn of the spinal cord and the gene that encodes AOX1 is located in a chromosomal region that is frequently found to be implicated in ALS2. This evidence suggests that AOX1 is a candidate gene for ALS2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。