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The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. AP3M1 is highly homologous to AP3M2 but is the preferred binding partner to the YQRL motif from the cytosolic domain of TGN38. AP3M1 has also been shown to interact with the HIV-1 virulence protein Nef.
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蛋白别名: adapter-related protein complex 3 mu-1 subunit; adapter-related protein complex 3 subunit mu-1; adaptor protein complex 3 Mu3A; adaptor related protein complex 3 mu 1 subunit; adaptor related protein complex 3 subunit mu 1; Adaptor-related protein complex 3 subunit mu-1; AP-3 adapter complex mu3A subunit; AP-3 adaptor complex mu3A subunit; AP-3 complex subunit mu-1; AP-3 complex subunit mu-1-like protein; ap3; clathrin adaptor complex AP3, mu-3A subunit; Mu-adaptin 3A; Mu3A-adaptin
基因别名: AP3M1; RCJMB04_1h22
UniProt ID: (Chicken) Q5ZMP7, (Bovine) Q24K11, (Human) Q9Y2T2
Entrez Gene ID: (Dog) 489052, (Chicken) 423736, (Bovine) 514761, (Human) 26985, (Horse) 100064191, (Chinese hamster) 100689277